Protein Info for GFF3562 in Variovorax sp. SCN45

Annotation: UDP-glucose 6-dehydrogenase (EC 1.1.1.22)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF03721: UDPG_MGDP_dh_N" amino acids 1 to 181 (181 residues), 182.1 bits, see alignment E=2.1e-57 TIGR03026: nucleotide sugar dehydrogenase" amino acids 1 to 421 (421 residues), 413.8 bits, see alignment E=3.5e-128 PF00984: UDPG_MGDP_dh" amino acids 205 to 297 (93 residues), 116 bits, see alignment E=1.7e-37 PF03720: UDPG_MGDP_dh_C" amino acids 321 to 424 (104 residues), 103.8 bits, see alignment E=1.5e-33

Best Hits

Swiss-Prot: 55% identical to UDG_PSEAE: UDP-glucose 6-dehydrogenase (udg) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00012, UDPglucose 6-dehydrogenase [EC: 1.1.1.22] (inferred from 81% identity to vpe:Varpa_5657)

Predicted SEED Role

"UDP-glucose dehydrogenase (EC 1.1.1.22)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) or Teichuronic acid biosynthesis (EC 1.1.1.22)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>GFF3562 UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (Variovorax sp. SCN45)
MKVSLFGAGYVGLSFAACLAEAGHEVLCTDADLARIEGLQRGLMPLHEPDLEALVAQGLA
AGTLRFTADAQAACAHGDVLFIAVGTPADAEGRVDLRHVMAVAAGIGRHREREALVVCKS
TAPVGTADQVEAVLSGELSRRGASLRIAVAANPEFLREGAAVRDCRRPDRVVIGTQDPWA
IDLLTRLYAPFVSEPERPLLVMDRRSAELTKYAANAMLATRISFMNEMARVAGHAGADIE
MVRRGIGADHRIGPDFLQAGAGYGGSCLAKDVRALTRMAERDGHALRILSAVEAANHEQK
GRLFDLMTHHFEGRIAGKTVAVWGLAFKPDTDDMRDAPSLVLLERLLAAGARVQAYDPAA
MANARAIVGERDGLRWCADAQEALQGADVLALVTEWPVFREVSLARIARELRMPAIFDGR
NVYDAAQVEAAGIAYYGIGRGRTAPR