Protein Info for GFF3515 in Variovorax sp. SCN45

Annotation: Potassium-transporting ATPase A chain (EC 3.6.3.12) (TC 3.A.3.7.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 599 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 60 to 81 (22 residues), see Phobius details amino acids 133 to 157 (25 residues), see Phobius details amino acids 176 to 198 (23 residues), see Phobius details amino acids 282 to 306 (25 residues), see Phobius details amino acids 312 to 333 (22 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 410 to 437 (28 residues), see Phobius details amino acids 457 to 479 (23 residues), see Phobius details amino acids 523 to 547 (25 residues), see Phobius details amino acids 565 to 589 (25 residues), see Phobius details PF03814: KdpA" amino acids 11 to 595 (585 residues), 801.5 bits, see alignment E=1.5e-245 TIGR00680: K+-transporting ATPase, A subunit" amino acids 242 to 596 (355 residues), 543.5 bits, see alignment E=2.9e-167

Best Hits

Swiss-Prot: 79% identical to KDPA_POLNA: Potassium-transporting ATPase potassium-binding subunit (kdpA) from Polaromonas naphthalenivorans (strain CJ2)

KEGG orthology group: K01546, K+-transporting ATPase ATPase A chain [EC: 3.6.3.12] (inferred from 91% identity to vpe:Varpa_5695)

Predicted SEED Role

"Potassium-transporting ATPase A chain (EC 3.6.3.12) (TC 3.A.3.7.1)" in subsystem Potassium homeostasis (EC 3.6.3.12, TC 3.A.3.7.1)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.12

Use Curated BLAST to search for 3.6.3.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (599 amino acids)

>GFF3515 Potassium-transporting ATPase A chain (EC 3.6.3.12) (TC 3.A.3.7.1) (Variovorax sp. SCN45)
MTSSAWGLLALFMAALLVLAWPVGKFLAALCNERVPRWMQRVEAPLYKLAGTKPEQSMHW
LRYALALLAFNAVGAIFLYALQRVQGWLPLNPAGMTAVSPDSAFNTAVSFVANTNWQGYA
GESTMSYLTQMLGLTVQNFLSAATGIAVAFALVRGFARRGDGKGLVGNFWADVTRITLWV
LVPVSFVLAMIFAGQGVIQNFDAYKEVSTLETTAFQQPKNGADGQPLKDEKGQPVMEDAT
TKTQTLAMGPVASQEAIKMLGTNGGGFFNANSAHPYENPTALVNLLQMIAIFLIPAALCF
TFGHVVGDMRQGWAVLAAMTIMFVIAVMVITPAEQAGNPLFTSLGVDQVSSALQAGGNME
GKELRFGIDASSLFAAVTTAASCGAVNAMHDSLTPLGGMVPMVLMQLGEVVFGGVGSGLY
GMLIFAMLAVFIAGLMIGRTPEYLGKKIEVREMKLISIAILVTPVLVLAGTAVAVIAGAG
KAGIANPGAHGFSEILYALTSAANNNGSAFAGLSANTPFYNGLLALAMWLGRFAMIVPVL
AVAGALAAKKRLPVTSGTLPTHGPLFVSLLIGTVLLVGLLNYVPALALGPIVEHLVLWK