Protein Info for GFF3509 in Variovorax sp. SCN45

Annotation: Multidrug efflux system, inner membrane proton/drug antiporter (RND type) => MexI of MexHI-OpmD system

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1026 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 336 to 355 (20 residues), see Phobius details amino acids 359 to 382 (24 residues), see Phobius details amino acids 387 to 409 (23 residues), see Phobius details amino acids 430 to 450 (21 residues), see Phobius details amino acids 462 to 489 (28 residues), see Phobius details amino acids 525 to 542 (18 residues), see Phobius details amino acids 845 to 864 (20 residues), see Phobius details amino acids 873 to 894 (22 residues), see Phobius details amino acids 900 to 923 (24 residues), see Phobius details amino acids 945 to 968 (24 residues), see Phobius details amino acids 977 to 1003 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1003 (1000 residues), 885 bits, see alignment E=9.9e-270 PF03176: MMPL" amino acids 328 to 484 (157 residues), 38 bits, see alignment E=1.5e-13 amino acids 846 to 1007 (162 residues), 25.8 bits, see alignment E=7.5e-10

Best Hits

KEGG orthology group: None (inferred from 80% identity to axy:AXYL_01441)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1026 amino acids)

>GFF3509 Multidrug efflux system, inner membrane proton/drug antiporter (RND type) => MexI of MexHI-OpmD system (Variovorax sp. SCN45)
MKFTDLFVRRPVLALVVSTLILLLGARALGDLPVRQYPLTESTTLTITTQYPGASPELMQ
GFVTQPIAQAVATIENVDYLSSSSTLGRSVISVRMKLNADANQALTQAMAQISQVKYRLP
AEAFDPVILKSSGEATAVAYVGFSSKTMPMPALTDYLSRVVQPQFASITGVSGVEVSGGQ
TLAMRVWLDPNRMAARGISAGELADALRQNNVQAAPGQVKGLYVVSNIRVNTDLVNVAEF
RDMVVKRDGDAIVRLGDVATVELGAASADSSATMDGVPAIYLGLQAAPNGNPLVIVKRIR
ELLPGIKQNLPPGVEVQLPFELARFIEASIDEVQKTLLEAIAIVVIVIFLCLGSVRAVLI
PVVTIPLSMLGAAALMLLFGFSINLLTLLAMVLAIGLVVDDAIVVVENVHRHIEEGKSRV
QAALIGAREVAGPVIAMTLTLAAVYAPIGLMGGLTGSLFKEFAFTLAGAVVVSGVIALTL
SPVMSSFLLPQDTTGSRMARAAEAFFHKLATGYGRLLDVSLHHRWVTGVFAALVLASLPF
LYNSAQRELAPGEDQAMVLTAIKSPQHANIDYVEKFGKKWDEVFAALPENTGRWLINGSD
GVSNSIGGVQLSDWKDRKRNADQIQGDTQGRMNDVEGSSVFAFQLPSLPGSTGGLPVQMV
IRSAADHRTVFEAMEALKKSARDSGKFIVVDSDLEFNNPTVEIRVDRAKANSLGVTMKSI
GDTLAVLVGENYVNRFGMDGRSYDVIPQSPREQRLTAEALSRYFVKSASGQPVPLANLVQ
LSTSVGPNKLTQFNQLNASTFQAIPAPGVTMGDAVAFLSEEAKKLPAGFSYDWQSDARQF
TQEGSALVMAFVFAIVVIYLVLAAQYESLRDPLIILISVPMSICGALVPLALGFGTINIY
TQIGLVTLIGLISKHGILMVEFANEIQMNKGLDRRASIEEAARIRLRPILMTTAAMVVGL
VPLLFASGAGANSRFSIGLVIVVGMLVGTLFTLFVLPTMYTLLARDHRAAGRSQRAAELE
ALAEGA