Protein Info for PS417_17930 in Pseudomonas simiae WCS417

Annotation: aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 46% identical to FEAB_ECOLI: Phenylacetaldehyde dehydrogenase (feaB) from Escherichia coli (strain K12)

KEGG orthology group: K00146, phenylacetaldehyde dehydrogenase [EC: 1.2.1.39] (inferred from 87% identity to pfs:PFLU3291)

MetaCyc: 76% identical to 4-hydroxyphenylacetaldehyde dehydrogenase (Pseudomonas putida U)
4-hydroxyphenylacetaldehyde dehydrogenase. [EC: 1.2.1.53]

Predicted SEED Role

"Phenylacetaldehyde dehydrogenase (EC 1.2.1.39)" in subsystem Aromatic Amin Catabolism (EC 1.2.1.39)

MetaCyc Pathways

L-phenylalanine degradation II (anaerobic) (2/3 steps found)
phenylethanol degradation (1/2 steps found)
phenylethylamine degradation I (1/2 steps found)
phenylethylamine degradation II (1/2 steps found)
styrene degradation (1/3 steps found)
L-phenylalanine degradation IV (mammalian, via side chain) (3/9 steps found)
aromatic biogenic amine degradation (bacteria) (2/8 steps found)
superpathway of phenylethylamine degradation (4/11 steps found)
anaerobic aromatic compound degradation (Thauera aromatica) (3/27 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.39 or 1.2.1.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UNB5 at UniProt or InterPro

Protein Sequence (495 amino acids)

>PS417_17930 aldehyde dehydrogenase (Pseudomonas simiae WCS417)
MSDIPLLPQVEAFLRRPHGLFIDGVNIRSHSSQTLAVTNPATGDVIAQVSDADLADIDAA
VNSANRGFQVWSQALPATRGNVLLKLADLLERNREELAQIETCQSGKIIQIARAFEVDQA
AHFLRYYAGWATKLSGQTLTPSLPSFNGERYTAFTLREPVGVVVGIVPWNFSTMIAIWKL
ASALVTGCSIIIKPSEFTPLTVLRIAELAVEAGLPPGVLNVLTGGGHVGKGLVEHPGTHK
VSFTGSVPTGIAVGRSAMGAGLTRATLELGGKNAAGFLRDVDVDTAVNGIIEAGFLHSGQ
ICAAAERFFVHRSQIDAVLDTLSQRLSRLNIGSPLDERTEFGPVTHHQHQLKLLGYFNQA
RAENNTIIHGGTLIDRPGCYVEPTVILANSINDTLLNEETFGPIATFLPYDSEDELLALM
NNGPYGLSASLWTNDLGKALRMVPAIQAGTLWVNMHTLLDPAVPFGGNRSSGVGREFGSA
FIEDYTELKSVMIRY