Protein Info for GFF3490 in Xanthobacter sp. DMC5

Annotation: Virulence sensor histidine kinase PhoQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 474 transmembrane" amino acids 18 to 44 (27 residues), see Phobius details amino acids 178 to 203 (26 residues), see Phobius details PF02518: HATPase_c" amino acids 356 to 466 (111 residues), 58.9 bits, see alignment E=3.2e-20

Best Hits

KEGG orthology group: None (inferred from 84% identity to xau:Xaut_3177)

Predicted SEED Role

"Sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (474 amino acids)

>GFF3490 Virulence sensor histidine kinase PhoQ (Xanthobacter sp. DMC5)
MAMDAARRPPEYTPGSLAFRLVLSAMAITVVVLLVVGFVLASLYRSSAERAFDRQLDIYL
KIIVADVANASERLPEPAALADPLFAFPNSGWYWQIALKSGGQLERRTSRSLVGASLPLL
AEQGIRGRPGLMRQGYATGPGGVALRIVERDVDLGADARYVVSVAAVASDLEAEISAFNF
SLAATLVVLACAFLLVVIVQVRFGLKPLTRISEALSDVRSGKAERLEGTYPIEIVPLVRE
VNALIDANHEIVERARTHVGNLAHALKTPLSVLMNEAGTRDDPLAVRVRDQAGVMRDQVA
HHLERARMAARISVVASVCEVTPVITSLARTMEKIHRTKDLAIDVRIPEDVHFRGEQQDL
EEMFGNLIDNACKWASSRVEVEVLVERPRTPGDRVYFHVSIDDDGPGLDPARRVDVGRRG
RRLDESKPGSGLGLSIVHELALLYGGRFELSSAPIGGLRTELVLPAAAAPPPPT