Protein Info for GFF3452 in Sphingobium sp. HT1-2

Annotation: Beta-lactamase class A-like and penicillin binding proteins (PBPs) superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF13354: Beta-lactamase2" amino acids 161 to 259 (99 residues), 53.5 bits, see alignment E=1.1e-18

Best Hits

KEGG orthology group: None (inferred from 41% identity to sal:Sala_1090)

Predicted SEED Role

"Beta lactamase-related protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (424 amino acids)

>GFF3452 Beta-lactamase class A-like and penicillin binding proteins (PBPs) superfamily (Sphingobium sp. HT1-2)
MRLLAVALVLIGMALLPGRAMADPAPAFRARATQLVTILAAPGNEADFFSPVFIDAIPVD
RWRALAADLRRQHGRPVALGAITQQSATAGQMEVRYERAIVAITLVIAPDPPNRVVGLRI
IGSRQADDSMAAVLRDIAALPGRSSFAIARLTDAGPVLLQSHHPDQPMATGSSFKLTVLA
ELARAVQAGERRWSDVIPLGPKSFSGRLMAWPDRAPMTLHSLATAMIAESDNSASDTLLL
GLDRDKVDAMRQRFGIADPRSLPMLTTAEAFALKMPANAELRRRYEGGTIADRRALLRDA
ATRLTAAHVDVGTVSENPVAIDTLEWFASPQEEIAQLDWLRRTGGDALSIMAVNPGIAPA
NAKRWRYFGYKGGSEPGVIAMNFLVQAQDGQFYAVSGAWNDPVARVDEGRFVMLMTRALN
LLAD