Protein Info for GFF3447 in Sphingobium sp. HT1-2

Annotation: Efflux ABC transporter, permease protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 282 transmembrane" amino acids 52 to 73 (22 residues), see Phobius details amino acids 85 to 109 (25 residues), see Phobius details amino acids 129 to 153 (25 residues), see Phobius details amino acids 165 to 189 (25 residues), see Phobius details amino acids 196 to 217 (22 residues), see Phobius details amino acids 252 to 274 (23 residues), see Phobius details PF01061: ABC2_membrane" amino acids 34 to 244 (211 residues), 94.3 bits, see alignment E=3.9e-31

Best Hits

KEGG orthology group: K09686, antibiotic transport system permease protein (inferred from 87% identity to sjp:SJA_C1-22220)

Predicted SEED Role

"ABC-type multidrug transport system, permease component"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (282 amino acids)

>GFF3447 Efflux ABC transporter, permease protein (Sphingobium sp. HT1-2)
MNDQPKIAAAHPAPVPFHEPGELVIRNVNWAGMRALYRKEVRRFMKVQLQTIWAPAVTTL
MFLVIFTIALGGANRQVLGVPFADFIAPGLMMMGMMNNAFANSSFSLLAGKMQGTLIDYL
MPPLSVGELLLALVGAAVTRAVAVGLALWGAMALWPGVHVTPTHLWAVIWFGLMGASLTA
FIGVMTSIWAEKFDHAAAITNFVIGPMTLLSGTFYSIDRLSPLFRAISHANPFFYAISGF
RYGFVAAADGNVLVGSVVLLALNAGLAVLCYVLLRKGWKLKA