Protein Info for GFF3343 in Sphingobium sp. HT1-2

Annotation: Polar-differentiation response regulator DivK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 53% identical to DIVK_OCHA4: Polar-differentiation response regulator DivK (divK) from Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)

KEGG orthology group: K11443, two-component system, cell cycle response regulator DivK (inferred from 89% identity to sjp:SJA_C1-00820)

Predicted SEED Role

"Chemotaxis protein CheV (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (120 amino acids)

>GFF3343 Polar-differentiation response regulator DivK (Sphingobium sp. HT1-2)
VAKRVLVVEDNELNLKLFCDLLRAHGHDVLPLRDGRDVLAQAREFAPDLVITDIHLPHVS
GYDLIVSLKGDDSLSAVPIMAVTAYAGKGDEDRIRAAGADAYVSKPISVLRFVEQVNALL