Protein Info for GFF331 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Permease of the drug/metabolite transporter (DMT) superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details transmembrane" amino acids 39 to 41 (3 residues), see Phobius details amino acids 55 to 74 (20 residues), see Phobius details amino acids 87 to 108 (22 residues), see Phobius details amino acids 115 to 134 (20 residues), see Phobius details amino acids 141 to 161 (21 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 199 to 220 (22 residues), see Phobius details amino acids 226 to 252 (27 residues), see Phobius details amino acids 264 to 285 (22 residues), see Phobius details amino acids 291 to 307 (17 residues), see Phobius details PF00892: EamA" amino acids 21 to 159 (139 residues), 69.8 bits, see alignment E=1.4e-23 amino acids 173 to 305 (133 residues), 75.3 bits, see alignment E=2.9e-25

Best Hits

Swiss-Prot: 100% identical to YICL_SALTY: Uncharacterized inner membrane transporter YicL (yicL) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: None (inferred from 99% identity to sei:SPC_3844)

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (315 amino acids)

>GFF331 Permease of the drug/metabolite transporter (DMT) superfamily (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MMPARKKIKQHDEEKMGSTRKGMLNVLIAAVLWGSSGVCAQYIMEQSRMSSQFLTMIRLL
FAGLILVTFSFMHGDKIFSILKNRKDALSLLIFSVVGALTVQLTFLLTIEKSNAATATVL
QFLSPTIIVAWFALARRTRPGILVLTAILTSLIGTFLLVTHGNPTSLSISSAALFWGIAS
AFAAAFYTTWPSRLIAQYGTLPVVGWSMSFGGLILLPFYAKEGTHFAVSGSLILAFFYLV
VIGTSLTFSLYLKGAQLIGGPKASILSCAEPLSSALLSLLLLGISFTLPDWLGTLLILSS
VILISLDSRRRARAA