Protein Info for PS417_16875 in Pseudomonas simiae WCS417

Annotation: signal peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 222 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details TIGR02227: signal peptidase I" amino acids 10 to 204 (195 residues), 151.9 bits, see alignment E=7.2e-49 PF10502: Peptidase_S26" amino acids 12 to 200 (189 residues), 142.7 bits, see alignment E=5.6e-46

Best Hits

KEGG orthology group: K03100, signal peptidase I [EC: 3.4.21.89] (inferred from 57% identity to slt:Slit_2283)

Predicted SEED Role

"Signal peptidase I (EC 3.4.21.89)" in subsystem Signal peptidase (EC 3.4.21.89)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.89

Use Curated BLAST to search for 3.4.21.89

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UH62 at UniProt or InterPro

Protein Sequence (222 amino acids)

>PS417_16875 signal peptidase (Pseudomonas simiae WCS417)
MRSWLIRYRYAIIFWMCFGVFRTSLADWNPIPSGSMRPTLLEGDVVLVNRVAYDLKVPLT
DISLARLDNPQRGDVVTFSSPKDGMRLIKRIVGIPGDTLEMKDEVLWVNGVPATYSDAQD
ISEPIVPGHTVPGIKLNEWVANRQRTVQFMPTVRALRDFGPVVVPAESYFMLGDNRDNSD
DSRYIGFVPRRLLIGRAHHVLASADILDHWMPRLNRFGAKIL