Protein Info for GFF3285 in Variovorax sp. SCN45

Annotation: ATP-dependent Clp protease ATP-binding subunit ClpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 775 PF07724: AAA_2" amino acids 515 to 673 (159 residues), 132.9 bits, see alignment E=4.1e-42 PF00004: AAA" amino acids 520 to 635 (116 residues), 37.1 bits, see alignment E=1.5e-12 PF07728: AAA_5" amino acids 520 to 636 (117 residues), 35.2 bits, see alignment E=4.2e-12 PF10431: ClpB_D2-small" amino acids 680 to 749 (70 residues), 56.2 bits, see alignment E=1e-18

Best Hits

KEGG orthology group: None (inferred from 48% identity to hch:HCH_05499)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpA" in subsystem Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (775 amino acids)

>GFF3285 ATP-dependent Clp protease ATP-binding subunit ClpA (Variovorax sp. SCN45)
VPQAARPPRRTEKEETRIRMATLSYPLVCWQLDDTSVCGILLGTDFQVIERNARRVKAAL
AETLQRERERDGYVPEPDIDEARLKLVHVSVSLAHRTEKGSFPVPRATDFHVAAVFGENE
EDGYAKCYLPWLDQSFYYYDDAQLPVLIEHYTRECLDGLSPEDAQRFLMPAAPWLDQIDV
RRDDRTTNRQHVPRHLREAHAQLDAVADRLPETGARRGLHVFPEVAWEQGALSDEIAARL
ARGGNLLLVGEPGVGKSVVILEAIRKAHRLTAARDAPPTFWRSHAERLVGRAKYLGEWQA
LCDQTVEWLDMSNGLLWVTDFVNLLQVGGESPEESMAAYLLPALRRGTLRLVGEANPSEL
EIARQRLPGFIDCFETLRLPEMDSVRARRVLDLFAGHAKNTLSIEIERPALDTGYRLLGR
YVRYDSFPGKAVRFFGDCVREAIAGQTGVVTEASAIAHFAKSTGLPESFLRDDQPLDDTQ
VHGFFAQKLFGQDAAIGHLKDVVYLFKAGLNDPAKPIATLLFAGPTGVGKTAAAKALARY
FFGAGDDADPLFRIDMSEFQHAFQIARLIGSGKRPGKLVEHVRRQPFSVVLLDEIEKADA
SVFDLLLTVLDEGRLRDSRGRMTDFRSTVIVMTTNLGVRHGASLGFGEPANGGGAVHDIR
QFFRPEFFNRIDRVVPFAPLSRTAIEAIAVQELQAIAQREGLARRGVRLNFSPEVVAFVA
DKGFSPKYGARPLQRAVEQHVVAAVARAMFGPVADGACLEVGLVDGVVVARPGLG