Protein Info for GFF3277 in Xanthobacter sp. DMC5

Annotation: Glutarate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 28 to 487 (460 residues), 567.6 bits, E=8.7e-175
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 39 to 485 (447 residues), 687.7 bits, E=3.7e-211

Best Hits

Swiss-Prot: 62% identical to DAVD_PSEAE: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 92% identity to xau:Xaut_3273)

MetaCyc: 62% identical to glutarate semialdehyde dehydrogenase (Pseudomonas aeruginosa)
Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.20]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• L-lactaldehyde degradation (aerobic) (2/2 steps found)
• methylglyoxal degradation IV (2/3 steps found)
• methylglyoxal degradation V (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• superpathway of methylglyoxal degradation (5/8 steps found)
• L-lysine degradation IV (2/5 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• L-lysine degradation I (3/7 steps found)
• L-rhamnose degradation II (3/8 steps found)
• L-lysine degradation III (1/6 steps found)
• superpathway of fucose and rhamnose degradation (4/12 steps found)
• superpathway of L-lysine degradation (13/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.22

Protein Sequence (492 amino acids)

>GFF3277 Glutarate-semialdehyde dehydrogenase (Xanthobacter sp. DMC5)
MAATQPAFKSEAHRFTLLRDKMLIGGAWVDADGGETISVNNPATGEIIGTIPKAGAAETR
RAIEAAAEAFKTWRATTAAERAGKLHKLADLILANADELALILTTEQGKPLAEAKGEIGA
SAAYVRWFAEEARRLYGDVIPSPWPNRRILVTKEPVGVCAAVTPWNFPSSMLSRKIGAAL
AAGCTVVCKPSELTPYSGLAWGVLAEMAGIPAGVVNIVVGDAPSIGGEMTSNPAVKKVTF
TGSTPVGKLLMKQSADTMKKISLELGGNAPFLVFDDADLDLAVEQAIASKYRNVGQTCVC
ANRFYVQAGIYDAFAAKFAEASKKLKVGNGVDEGVVAGPLIDARALAKVERLLKDALDKG
ASILTGGKQPALGGTFFEPTVLANATQDMAFARDEIFGPLAPLFKFETEEEAVSYANATE
YGLACYFFTKDLGRAFRVSEQLQYGQVGVNAGVITTEVAPFGGVKESGVGREGSKYGCDD
YLNIKYVCMGGI