Protein Info for GFF3269 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Two-component hybrid sensor and regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1156 transmembrane" amino acids 63 to 86 (24 residues), see Phobius details amino acids 92 to 115 (24 residues), see Phobius details amino acids 129 to 152 (24 residues), see Phobius details amino acids 170 to 191 (22 residues), see Phobius details amino acids 200 to 217 (18 residues), see Phobius details amino acids 237 to 256 (20 residues), see Phobius details amino acids 277 to 306 (30 residues), see Phobius details amino acids 327 to 348 (22 residues), see Phobius details amino acids 379 to 399 (21 residues), see Phobius details amino acids 406 to 425 (20 residues), see Phobius details amino acids 446 to 468 (23 residues), see Phobius details amino acids 475 to 495 (21 residues), see Phobius details amino acids 581 to 603 (23 residues), see Phobius details amino acids 631 to 651 (21 residues), see Phobius details PF00512: HisKA" amino acids 697 to 763 (67 residues), 63.2 bits, see alignment 2.9e-21 PF02518: HATPase_c" amino acids 811 to 921 (111 residues), 96.1 bits, see alignment E=2.7e-31 PF00072: Response_reg" amino acids 948 to 1062 (115 residues), 56.9 bits, see alignment E=3.3e-19

Best Hits

KEGG orthology group: None (inferred from 74% identity to pna:Pnap_0978)

Predicted SEED Role

"Two-component hybrid sensor and regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1156 amino acids)

>GFF3269 Two-component hybrid sensor and regulator (Hydrogenophaga sp. GW460-11-11-14-LB1)
VNPAVPPPSSVPASAPPPAGQDAPQRIIKVRRDYNSWVGSETMEDYALRYTPQRFRKWSE
WRVANTAFGAASFLILEAVGATLLVQYGFVNAALAILCTGLIIFLGGLPISVYAARHGVD
MDLLTRGAGFGYIGSTITSLIYASFTFIFFALEAAVMAYALELALDIPPAWGYLICALVV
IPLVTHGVSVISRFQVWTQPLWIVMMVVPFGAVAWMAPETFTNVVRYGGESGAGAVFDWH
LFGAALTVGIALITQMGEQADYLRFMPAKEPGHALRWWLGVLAGGPGWVVLGVVKMLGGA
LLAYLAISHMVPPERAVDPNQMYLAAYEFVFSDYGWAVAATALFVVVSQLKINVTNAYAG
SLAWSNFFSRITHSHPGRVVWVVFNTLIAFMLMEMNVFQALGEVLGLYSNIAIAWIMAVV
ADLVINKPLGWSPKGIEFKRAYLYDINPVGVGAMGLASALSIVAHMGLLGPTAQAFSAVI
AMVTALITAPAIAWITQGRYYIARQSTGGVSRTCVICEREYEAPDMAHCPAYQGHICSLC
CTLDARCGDLCKPHARLSEQWMGALRRVLPRRVWPYLEAGLAHYLLLMMIVAPVLAAVLG
LLYRQEVEGLAQGLGVAANTSLLDAALRSGFVRVYAVLLLIAATVAWWLVLAHKSREVAQ
EESNRQTRLLMQEIESHQRTDEALQQARRAAEQANQAKTRYISTISHELRTPLNSILGYA
QLLQEDPGVAPHRAQAIRVIHRGGEHLLSLIEGTLDIARIESGKLALDVRPMAFADAMRE
VASMFELQAAAKGLRFSYDTGSRLPDTVRADEKRLRQILINLLGNAVKFTRSGEVRLRVA
HAREMAQFEVHDTGPGMGQQDLDRVFEPFARGQGEAVAHGAATGTGLGLTIAKMLADLMG
GEMTVRSTPGQGSVFTVRLFLPELHGVQLPAPAALPLHAGYQGMRRRVLVVDNEEADREL
LARWLAPLGFEVMLATSGHDALALLDGLQPGEPGAPHAVFMDLAMPGIDGWETLRRLRAR
GWGTVPMAIVSANAFDKGLDNDLGHRPQDFFVKPVRREDLLAWLGQRLSLAWITEAAPER
ASVPVAAAAPATRDELEPLLELVRLGYYKGIVQWLDEWVQRRPEQAVFAQGLRTLAREFR
FETIEQQLLQHHVAPG