Protein Info for GFF322 in Variovorax sp. SCN45

Annotation: GTP cyclohydrolase II homolog

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 380 PF12471: GTP_CH_N" amino acids 2 to 159 (158 residues), 231.3 bits, see alignment E=8.4e-73 PF00925: GTP_cyclohydro2" amino acids 200 to 335 (136 residues), 53.3 bits, see alignment E=2.6e-18

Best Hits

Swiss-Prot: 57% identical to URG1_SCHPO: Uracil-regulated protein 1 (urg1) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)

KEGG orthology group: None (inferred from 98% identity to vpe:Varpa_3245)

Predicted SEED Role

"GTP cyclohydrolase II homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (380 amino acids)

>GFF322 GTP cyclohydrolase II homolog (Variovorax sp. SCN45)
VVGTTTKRAHRNVIGTHSGSYSVYRALAVASGALKREHKADLTNTAPTDVIGPYPQWSEP
GRIVSLDPWGAQVADVFAAELAAGYDIRPTIAITKAHVILPEVIEALQSGRLKADGHFLT
TGGAAMVTKAAIEPVWYLPEVARRFGCSETDLRRTLFEETGGMYPELVTRSDLEVFLPPI
GGQTLYIFGNPRDLANPAVELTARIHDECNGSDVFGSDICTCRPYLTHAIEECIMGAQRG
GVGLIAYSRKEGRALGEVTKFLVYNARKRQVGGDTADQYFARTECVAGVQDMRFQELMPD
VFHWLGIRKIHRLVSMSNMKFDAITGSGIEIGERVNIPDELIPADARVEMDAKMAAGYFT
PGPVPDAEELKKAKGRGLSE