Protein Info for GFF3216 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Pantothenate kinase (EC 2.7.1.33)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to COAA_SALPC: Pantothenate kinase (coaA) from Salmonella paratyphi C (strain RKS4594)

KEGG orthology group: K00867, type I pantothenate kinase [EC: 2.7.1.33] (inferred from 98% identity to ses:SARI_03523)

MetaCyc: 96% identical to pantothenate kinase (Escherichia coli K-12 substr. MG1655)
Pantetheine kinase. [EC: 2.7.1.34]; Pantothenate kinase. [EC: 2.7.1.34, 2.7.1.33]

Predicted SEED Role

"Pantothenate kinase (EC 2.7.1.33)" in subsystem Coenzyme A Biosynthesis (EC 2.7.1.33)

MetaCyc Pathways

superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
phosphopantothenate biosynthesis I (4/4 steps found)
phosphopantothenate biosynthesis II (1/3 steps found)
superpathway of coenzyme A biosynthesis II (plants) (5/10 steps found)

KEGG Metabolic Maps

Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.33 or 2.7.1.34

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (316 amino acids)

>GFF3216 Pantothenate kinase (EC 2.7.1.33) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MSIKEQSLMTPYLQFDRSQWAALRDSVPMTLTEDEIAQLKGINEDLSLEEVAEIYLPLSR
LLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRR
VELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIY
DVIPEGDKTVAQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEELLQTWY
INRFLKFREGAFTDPDSYFHNYAKLSKEEAVNTATSLWKEINWLNLKQNILPTRERASLI
MTKSANHAVEQVRLRK