Protein Info for GFF3195 in Sphingobium sp. HT1-2

Annotation: Prolyl endopeptidase (EC 3.4.21.26)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 736 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF02897: Peptidase_S9_N" amino acids 51 to 456 (406 residues), 345.2 bits, see alignment E=5e-107 PF00326: Peptidase_S9" amino acids 517 to 727 (211 residues), 198.3 bits, see alignment E=1.1e-62

Best Hits

KEGG orthology group: K01322, prolyl oligopeptidase [EC: 3.4.21.26] (inferred from 78% identity to sch:Sphch_1874)

Predicted SEED Role

"Prolyl endopeptidase (EC 3.4.21.26)" (EC 3.4.21.26)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.26

Use Curated BLAST to search for 3.4.21.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (736 amino acids)

>GFF3195 Prolyl endopeptidase (EC 3.4.21.26) (Sphingobium sp. HT1-2)
MRALRRLIWPLPALLAVIAAAPASAVAAAPSGDATPAAIDATPPDNGLHYPRTRRQDLVE
DHFGVKVTDPYRWLENDVRTDPAVRDWVGRENDLTRRYIDDLPGRDALKSRMQALFAHGR
FTVPRKAGTRYFYGYNKGLQNQTPLYVREGLAGEQRLLLDPNRWARDGASALAEWTPSPD
GRFLAYGVQDAGSDWRTLRVLDVDSGKILDDKVEWVKFSQTAWDGRGEGFFYSRYAAPVD
GEAYQSTNSDQQLYYHRIGTPQAQDQLIYATPDRPGLSHTAQVTSDGRWLIVSSFAGMDP
RRELHVAALDGGPVKLRTLVKGLANDWRLIGSRGSTLYFVTDRKAAHMRLVTLDALRPGR
SEKPLVAERADTLAGGSLVGNRFILAYMTQSETVAELVELDGRKVGDVPLPGMGTAAGFG
GRDGDPETFFSFSGFVTPASIYRFDTASQQTQLFAQPDLPFNPADYGVEQVSYPSKDGTL
IPLTILRKKVLADHAQAVPTILYGYGGFNIALTPGYSATRMAWLEQGGAYAIANLRGGGE
FGKAWHDAGRGANKQNVFDDFIAAAEYLKAQGYTPKDGLAIEGRSNGGLLVGAVVNQRPD
LFAAALPAVGVMDMLRFDRFTAGRYWVDDYGSPDNERDFPLLYSYSPYHNILSGKDYPAI
LVTTADTDDRVVPAHSFKYAAALQAASIGDKPHLLRVENRAGHGAGKPIDKLIEEYADSY
AFAAHFTGLDIRRKPD