Protein Info for GFF3160 in Variovorax sp. SCN45

Annotation: Transcriptional regulator YeiE, LysR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 329 PF00126: HTH_1" amino acids 33 to 92 (60 residues), 57.6 bits, see alignment E=1.5e-19 PF03466: LysR_substrate" amino acids 115 to 317 (203 residues), 158.9 bits, see alignment E=1.8e-50 PF12727: PBP_like" amino acids 182 to 283 (102 residues), 29.5 bits, see alignment E=5.9e-11

Best Hits

Swiss-Prot: 45% identical to YEIE_ECO57: Uncharacterized HTH-type transcriptional regulator YeiE (yeiE) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 92% identity to vpe:Varpa_4401)

Predicted SEED Role

"LysR family transcriptional regulator YeiE" in subsystem YeiH

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (329 amino acids)

>GFF3160 Transcriptional regulator YeiE, LysR family (Variovorax sp. SCN45)
MLGIPHQAEKRRISLTMTGKTDQSSAQRLRLNLRQLVVFVATARGGSTRAAADRIARSQS
AASSALADLETSVGVLLFDRIGRRLVLNENGRALLPKAQALLDQAGEVQALFSAEHAAPL
RVAASFTIGEYLLPERVSQWTALHPQSQVRLHIANTRDVIEAVAGFDVDVGFIEGPQTHP
DLVVRAWRSDELVIVAAPGHALAGRVATHKQLSQATWVLREHGSGTRQVTDAWLIQNLEQ
VNVGFELGSTEAIKRVVASGTGLACLSRYTVAQALEDGHLVELRTRLPAGVRKLATVMHR
DKLLGGATADFLRHCGATVPRTATAAAAR