Protein Info for GFF3148 in Xanthobacter sp. DMC5

Annotation: Crotonyl-CoA reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 338 PF08240: ADH_N" amino acids 31 to 126 (96 residues), 74.2 bits, see alignment E=1.4e-24 PF00107: ADH_zinc_N" amino acids 167 to 301 (135 residues), 94.8 bits, see alignment E=6.4e-31 PF13602: ADH_zinc_N_2" amino acids 199 to 336 (138 residues), 86.3 bits, see alignment E=5.5e-28

Best Hits

KEGG orthology group: None (inferred from 83% identity to mrd:Mrad2831_5822)

Predicted SEED Role

"putative dehydrogenase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (338 amino acids)

>GFF3148 Crotonyl-CoA reductase (Xanthobacter sp. DMC5)
MTKTMKALLLKQHGDVSDLVVVNDYPVPSPKPGEVVIRVGASSFNYHDVFTVKGMPGIKV
PLPVIIGLDMAGEIVELGEGVTGWSVGDRVLVNPLNPKVGLMGEMMDGGMAEYCAVTAGQ
LIKMPDGVSFVEAASLPVAYGTAHRMLVTHNTVKAGDKVLILGASGGVGTGCVMLAKQMG
CEVIACAGSDDKMARLKELGADHVVNYRTTDFSKWAVEKYGKPQRRTYEGGVDVVVNFTG
GDTWVPSLRCVKRGGTILVCGATAGHDPKEDLRYIWSFELKVIGSNSFYHENLSALMDMI
QKGELKPVVDKVLPLEEAAEGLRMIRDREVMGKIVVTP