Protein Info for GFF3134 in Xanthobacter sp. DMC5

Annotation: ATP phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00070: ATP phosphoribosyltransferase
  • amino acids 6 to 209 (204 residues), 176.6 bits, E=2.4e-56
• PF01634: HisG
  • amino acids 56 to 212 (157 residues), 130.1 bits, E=3.8e-42

Best Hits

Swiss-Prot: 67% identical to HIS1_NITWN: ATP phosphoribosyltransferase (hisG) from Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)

KEGG orthology group: K00765, ATP phosphoribosyltransferase [EC: 2.4.2.17] (inferred from 93% identity to xau:Xaut_4747)

Predicted SEED Role

"ATP phosphoribosyltransferase (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• L-histidine biosynthesis (10/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Histidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.17

Use Curated BLAST to search for 2.4.2.17

Protein Sequence (325 amino acids)

>GFF3134 ATP phosphoribosyltransferase (Xanthobacter sp. DMC5)
MTTPLILAVPSKGRLQENVHAFFSRAGMPLTQARGARDYRGALGGVEGVEVAYLSASEIA
AALASGTAHLGVTGEDLVRENIHEADSRVALLEKLGFGHANVVVAVPQAWIDVRTMDDLD
DVASHFHGRTGRRIRVATKYVNLTRGYFARHGIIDYRIVESAGATEGTPAAGTAELIVDI
TTTGATLAANALKVVDDGIILKSEANLVASLTANWSGGALAAARAMFDRLGAEKRARTMR
EVRTRFADCDASLVDEAVAAYRCVAPFGGPTSSGMLTLHCPPDTLHALATFLRQRGASMV
TVGPIEYVFAADNPLYEALEARLDG