Protein Info for GFF3111 in Sphingobium sp. HT1-2

Annotation: Subclass B3 beta-lactamase (EC 3.5.2.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 308 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00753: Lactamase_B" amino acids 58 to 198 (141 residues), 54.1 bits, see alignment E=2.1e-18 PF12706: Lactamase_B_2" amino acids 94 to 188 (95 residues), 31.9 bits, see alignment E=1e-11

Best Hits

KEGG orthology group: None (inferred from 57% identity to sjp:SJA_C2-03650)

Predicted SEED Role

"beta-lactamase-like protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (308 amino acids)

>GFF3111 Subclass B3 beta-lactamase (EC 3.5.2.6) (Sphingobium sp. HT1-2)
MRNWMGVGISMAAMFLGGPAWTKAADDPLLRPIALASSKRWLAPQAPIRLHGQTYLVGFG
GLNVALIRTSAGLILIDGAVPQAVRDVEANIRALGFSIRDVKLILSTEPHFDHAGGLAAL
ARDSGATVVASAPAKAVLRTGGIDPADPQAAWLERFPAVRRLRAVKDGEEIRLGDTVITA
VATPGHTMGSMSWRWKSCEGRQCATMVFGSSLNPIAADGYAFSDPAHRPVVDAFRATFAK
VGALDCDLLITAHPDPADPAKLARLRAKRVPNAFIDPTACRRYADRAAGMLDKKLAAEGE
TRSYSRGQ