Protein Info for GFF3111 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Indole-3-glycerol phosphate synthase (EC 4.1.1.48)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00218: IGPS
  • amino acids 5 to 264 (260 residues), 311.6 bits, E=1.7e-97

Best Hits

Swiss-Prot: 80% identical to TRPC_VARPS: Indole-3-glycerol phosphate synthase (trpC) from Variovorax paradoxus (strain S110)

KEGG orthology group: K01609, indole-3-glycerol phosphate synthase [EC: 4.1.1.48] (inferred from 81% identity to adk:Alide2_4385)

Predicted SEED Role

"Indole-3-glycerol phosphate synthase (EC 4.1.1.48)" in subsystem Tryptophan synthesis (EC 4.1.1.48)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• superpathway of chorismate metabolism (43/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.48

Protein Sequence (266 amino acids)

>GFF3111 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSDILQKIVAVKHEEIAAAQRKKPLDAVRFDAESRVLTRDFEGALRAKIAAGQAAVIAEV
KKASPSKGVLREDFIPADIAQSYAEGDGQVSAACLSVLTDRQFFQGSPDFLKQARASCDL
PVLRKDFMVDPYQVYEARAMGADAILLIAACLDDARMAELEAVAQGLNMAVLVEVHDRAE
LERALRLKTRLVGINNRNLRTFEVTLQTTLGMLPDVPADRLLITESGILGRDDVQTMRAA
GVNAFLVGEAFMRAPEPGLALAELFA