Protein Info for GFF3110 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02885: Glycos_trans_3N
  • amino acids 12 to 73 (62 residues), 59 bits, E=3.2e-20
• TIGR01245: anthranilate phosphoribosyltransferase
  • amino acids 15 to 346 (332 residues), 417.2 bits, E=2.5e-129
• PF00591: Glycos_transf_3
  • amino acids 83 to 338 (256 residues), 307.8 bits, E=6.7e-96

Best Hits

Swiss-Prot: 86% identical to TRPD_POLSJ: Anthranilate phosphoribosyltransferase (trpD) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K00766, anthranilate phosphoribosyltransferase [EC: 2.4.2.18] (inferred from 86% identity to pol:Bpro_4452)

Predicted SEED Role

"Anthranilate phosphoribosyltransferase (EC 2.4.2.18)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 2.4.2.18)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• superpathway of chorismate metabolism (43/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.18

Use Curated BLAST to search for 2.4.2.18

Protein Sequence (349 amino acids)

>GFF3110 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSPTSAHKITPQEALQRTIEHREIFHDEMLHLMRLIMSGEMSPVMMAALITGLRVKKETI
GEITAAAQVMREFSTKVHVADKTHLVDIVGTGGDGSHTFNISTCAMFVAAAAGARVSKHG
GRSVSSKSGSADVLESLGVNINLAPEAIARCIEQVGVGFMFAPNHHPAMKNVAPVRRELG
IKTIFNILGPLTNPASAPNILMGVFHPDLVGIQVRALQRLGAEHAVVVYGRDGMDEVSLG
AATLVGELRNGEITEYEIHPEDFGMTMASSRALRVETPEASRQMLLGVLESRDDPSFKAA
SEIVALNAGVALYAANVAADMGAGIALARRTLASGAALAKLEQLKAFVA