Protein Info for PS417_15870 in Pseudomonas simiae WCS417

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 537 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 40 to 62 (23 residues), see Phobius details amino acids 82 to 104 (23 residues), see Phobius details amino acids 116 to 134 (19 residues), see Phobius details amino acids 141 to 163 (23 residues), see Phobius details PF00512: HisKA" amino acids 180 to 244 (65 residues), 48.2 bits, see alignment E=1.4e-16 PF02518: HATPase_c" amino acids 289 to 393 (105 residues), 77 bits, see alignment E=2.3e-25 PF00072: Response_reg" amino acids 422 to 526 (105 residues), 38.5 bits, see alignment E=1.8e-13

Best Hits

KEGG orthology group: None (inferred from 83% identity to pfo:Pfl01_3253)

Predicted SEED Role

"Sensor histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UAX1 at UniProt or InterPro

Protein Sequence (537 amino acids)

>PS417_15870 histidine kinase (Pseudomonas simiae WCS417)
MSLETNSELDQANLRIVVASIAIVYIGALGFLPGQSVDTYLPVILYIFLFLLASIVLRQV
IARWPGHYPARRIFGMLHDYTGTSFGMVVGGEAALPLYAVMVWVNLGNGMRYGSRYLAIA
TALALLALLIVYRLTPVWQAQPFMVLMLMITSTVIPVYAHILLERTRKASEQAIAANLEK
SRFLAQASHDLRQPIHSIGLFTACLREARLGDEERRLVDNIDRSLLNVSQLFRSILDLYT
LDNGRLMPKYQAVHLGEFLADLVRQNAEAARWAGVELRLRPCAHWVLVDPALLATMVQNV
LSNCFKYGAHRPVLIGVRVRDGGLAVEIHDRGRGIAEEHLSKVFEEFYRVRHLRDKDVEG
VGLGLSIVKRLGQLMGVQVSLRSRVGHGTSVCLYGLTLATAPRTTAPRDDTRQAGLLTGL
KVCLVEDDHNVLLATQALLERWGCEVQAESSGRDLVSDCDIIVADYDLGNHATGIECIDA
LRAQRGWAVPALILTGHDVEKIQAALYDRQIAILSKPVRPAELRGSLRDLSQESVTG