Protein Info for PS417_15825 in Pseudomonas simiae WCS417

Annotation: Crp/Fnr family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 248 PF00027: cNMP_binding" amino acids 47 to 130 (84 residues), 50.3 bits, see alignment E=1.9e-17 PF13545: HTH_Crp_2" amino acids 164 to 238 (75 residues), 55 bits, see alignment E=6.5e-19

Best Hits

Swiss-Prot: 44% identical to FNR_PASMU: Anaerobic regulatory protein (fnr) from Pasteurella multocida (strain Pm70)

KEGG orthology group: K01420, CRP/FNR family transcriptional regulator, anaerobic regulatory protein (inferred from 78% identity to pfo:Pfl01_3345)

Predicted SEED Role

"transcriptional regulator, Crp/Fnr family" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U0C0 at UniProt or InterPro

Protein Sequence (248 amino acids)

>PS417_15825 Crp/Fnr family transcriptional regulator (Pseudomonas simiae WCS417)
MTGTRPLQVQSLKSACSQCSVLELCLPIGLSGDEVKRLDKLIVQRFKIKKGTALYRTGDP
LRSLYAVRVGSFKTSMVSVDGREQVTGFQIPGEMLGLDAISADIHACSAFALEDSEVCPI
HFAQLEKLSQSLPSLQHNLNRLLSREIVRDQTMLMLMGNMNSDERLAAFLLNLSQRLSIR
GYSPKDFVLKMRREEIGSYLGLRLETICRGIAHLRDLNLVDIAGRNVKIQDMEGLKQLVS
GCNRPTVL