Protein Info for PS417_15610 in Pseudomonas simiae WCS417

Annotation: GDP-mannose pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 195 TIGR00052: nudix-type nucleoside diphosphatase, YffH/AdpP family" amino acids 10 to 188 (179 residues), 161 bits, see alignment E=1.2e-51 PF00293: NUDIX" amino acids 46 to 155 (110 residues), 27.8 bits, see alignment E=1.2e-10

Best Hits

Swiss-Prot: 59% identical to NUDK_PECAS: GDP-mannose pyrophosphatase NudK (nudK) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: None (inferred from 96% identity to pfs:PFLU3608)

MetaCyc: 54% identical to GDP-mannose hydrolase (Escherichia coli K-12 substr. MG1655)
3.6.1.-

Predicted SEED Role

"Nudix hydrolase family protein YffH" in subsystem Nudix proteins (nucleoside triphosphate hydrolases)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U4K1 at UniProt or InterPro

Protein Sequence (195 amino acids)

>PS417_15610 GDP-mannose pyrophosphatase (Pseudomonas simiae WCS417)
MDNSPVRMTAEETLSENWYLLKKYSFNLRRRDGSWQAQTREVYDRGNGATILLYNREQRT
VLLIRQFRMPTFVNDYHGYLIEAAAGLLDNASPEERIRLEAEEETGYRVGHVEKIYAAFM
SPGSVTERIHFFMGEYQPGDRVGSGGGLEEEGEDIEVLELGFDEALAMVQNGEIVDGKTI
MLLQHLELRMLKDGW