Protein Info for GFF3043 in Xanthobacter sp. DMC5

Annotation: Error-prone DNA polymerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1099 TIGR00594: DNA polymerase III, alpha subunit" amino acids 193 to 1012 (820 residues), 468.1 bits, see alignment E=3.3e-144 PF07733: DNA_pol3_alpha" amino acids 301 to 555 (255 residues), 287.5 bits, see alignment E=2.2e-89 PF17657: DNA_pol3_finger" amino acids 558 to 731 (174 residues), 177 bits, see alignment E=4.1e-56 PF14579: HHH_6" amino acids 805 to 893 (89 residues), 67.2 bits, see alignment E=2.4e-22 PF01336: tRNA_anti-codon" amino acids 982 to 1051 (70 residues), 38.1 bits, see alignment 2.5e-13

Best Hits

Swiss-Prot: 62% identical to DNAE2_BRUAB: Error-prone DNA polymerase (dnaE2) from Brucella abortus biovar 1 (strain 9-941)

KEGG orthology group: K14162, error-prone DNA polymerase [EC: 2.7.7.7] (inferred from 62% identity to bmb:BruAb1_0069)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1099 amino acids)

>GFF3043 Error-prone DNA polymerase (Xanthobacter sp. DMC5)
VSAPVYAELAAASHFSFLRGASAPAHLVRTAVGLGLDGLGIADRNTVAGVVRAYSALEDL
RALDEDLEADDPEADAKRAVAARARAFRLVTGARLVFCDGTADIIAYPSTRAGWGRLCRL
LTTGNRRAKKGDCHLSLADLLADVRDLMLIVMPGEDGSDLPPLLSRLGEAAPGAVWLGVD
MPFSGADRRRLAALKAIARTACVPLLAVNDVLYATPEERDLQDILTCVRESTTIAEAGRR
LLANAERHLKPAAEMARLFRDAPEAVAESGALLARIDFTLKELKYDYPEEPVPPGWTPQA
WLEELTWRCAAVRYPEGVPEKVEKLLRDELALIRKLKYAPYFLTIHDIVRFAESQGILCQ
GRGSAANSAVCYVLGITAVDPADNDLLFARFISEERREPPDIDVDFEHARREEVIQHIYD
KYGRHRAGIVATVIHYRPRSAIRDVGKALGLTEDVTARLASTQWGSWGRDISDAHIREAG
LDPSNPFIRRAVELAGRLMGAPRHLSQHVGGFVLARGRLDDTVPIGNAAMADRTFIEWDK
DDIDVLGLMKVDVLALGMLTCIRKALDLMRNHEGIDWGLADVPSGQADVYAMLSRGDSIG
VFQVESRAQINMLPRLKPQKFYDLVIQVAIVRPGPIQGDMVHPYLRRRSGLEKVDYPSPA
PHLGDKDELHSVLDKTLGVPLFQEQAMKLAMVAARFSAKEANRLRRAMATFRNLGTIQEF
ESMMVERMVARGYKRDFAARCFEQIKGFGSYGFPESHAASFAKLVYISSYIKCRHPAAFA
CALLNAQPMGFYAPAQIVRDAHEHGVEVRPIDVNFSHHDNTLERRDDGALALRLGFRQVD
GFHAEWGERLAAARSGPFASIEDLARRARLPTRAVKLLADADAFRSMDLDRRAALWHARR
LPDDDALPLFAAADARELGVEEEVTLPRMARSEHIVADYQTVRLSLKGHPMGELRDHFRK
ERILTCAETSALKDGAFVRNAGVVLVRQRPGNGKAIFITIEDETGITNIVLWERTLERFR
REVMGARLLLVEGRIQKSPEGVVHLMAQRLTDRTADLALLSRVRQPRMEVARADEFAHPQ
HPRKHPRDARVLPKSRDFH