Protein Info for PS417_15570 in Pseudomonas simiae WCS417

Annotation: excinuclease ABC subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 838 TIGR00630: excinuclease ABC subunit A" amino acids 139 to 823 (685 residues), 741.7 bits, see alignment E=7.3e-227 PF17755: UvrA_DNA-bind" amino acids 168 to 281 (114 residues), 43.3 bits, see alignment E=1e-14

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 70% identity to cpi:Cpin_6311)

Predicted SEED Role

"Excinuclease ABC subunit A paralog of unknown function" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U078 at UniProt or InterPro

Protein Sequence (838 amino acids)

>PS417_15570 excinuclease ABC subunit A (Pseudomonas simiae WCS417)
MTSQRNTPAITAQQTGFVRVRGAREHNLRNVDVDIPRDALVVFTGVSGSGKSSLAFSTVY
AEAQRRYFESVAPYARRLIDQVGVPDVDSIEGLPPAVALQQQRGTPSARSSVGSVTTLSS
LIRMLYSRAGSYPPGQPMLYAEDFSPNLPQGACPQCHGLGRVYEVTEALMVPDPSLTIRQ
RAVASWPLAWQGQNQRDILVTLGYDVDIPWRDLPKKQRDWILFTEETPTVPVYAGFTPEQ
TRDALKRKLEPSYQGTFMGARRYILHTFAHTQSALMKKRVSQFMQGSACPLCEGKRLTKA
ALSVKFAGVDIGELSQLSLAQLAELLRPVAAGQDTMKLSVEKRLAAQRIAQDLLERVSTL
TELGLGYLSLERSTPTLSSGELQRLRLATQLGSQLFGVIYVLDEPSAGLHPADGEALFTA
LDRLKAAGNSLFVVEHDLETMRRADWLIDVGPAAGEHGGQVLYSGPPAGLAQVQASQTRA
YLFAEKRVSKQERRDPTGWLTLQGVTRNNLKDLNVDFPLGCFTAVTGISGSGKSSLVSQA
LLELVSAGLGRVVENDEEPSLEDDAPQTSGGHIHAGLEHIRRLVQVDQKPIGRTPRSNLA
TYTGLFDNVRKLFAATPAAKKRHYDAGQFSFNVAKGRCPNCEGEGFVSVELLFMPSVYAP
CPTCHGARYNPETLAVKWQGLTIAQVLGLTVEQAVEVFAEQPSVLRSLQVLRDIGLGYLR
LGQPATELSGGEAQRIKLATELQRNARGATLYVLDEPTTGLHPRDVDRLLSQLNHLVEAG
HTVVVVEHEMRVVAQSDWVIDIGPGAGDLGGAVVASGTPQKVAKSKKSRTAAFLAKAL