Protein Info for GFF3026 in Sphingobium sp. HT1-2

Annotation: Oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 3 to 186 (184 residues), 175.9 bits, E=1.4e-55
• PF08659: KR
  • amino acids 4 to 181 (178 residues), 40.5 bits, E=5.6e-14
• PF01370: Epimerase
  • amino acids 5 to 117 (113 residues), 21.9 bits, E=2e-08
• PF13561: adh_short_C2
  • amino acids 9 to 221 (213 residues), 127.8 bits, E=1.1e-40

Best Hits

Swiss-Prot: 70% identical to SDH_AGRFC: Serine 3-dehydrogenase (sdh) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: None (inferred from 79% identity to sch:Sphch_1393)

MetaCyc: 55% identical to 3-hydroxy acid dehydrogenase YdfG (Escherichia coli K-12 substr. MG1655)
RXN-16000 [EC: 1.1.1.381]; RXN-8974 [EC: 1.1.1.381, 1.1.1.298]; Serine 3-dehydrogenase. [EC: 1.1.1.381, 1.1.1.298, 1.1.1.276]

Predicted SEED Role

"Oxidoreductase"

MetaCyc Pathways

• uracil degradation III (5/5 steps found)
• 3-hydroxypropanoate cycle (10/13 steps found)
• superpathway of L-threonine metabolism (13/18 steps found)
• β-alanine degradation III (1/2 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (12/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (12/18 steps found)
• glyoxylate assimilation (8/13 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.276 or 1.1.1.298 or 1.1.1.381

Protein Sequence (248 amino acids)

>GFF3026 Oxidoreductase (Sphingobium sp. HT1-2)
MTKTVLITGATAGIGEAAVRAFAADGWQVIGTGRRADRLEKLAAEIGDAFCPLVFDMRDE
AAIDAALASLPEAFRAIDMLVNNAGLALGTAPAQSADLAQWQQMIETNITGLVTVTHKLL
PGLVARKGGIINLSSVAATYPYTGGNVYGGTKAFVRQFSLGLRSDLHGTGVRVTSIEPGM
VETEFTLVRTGSQQASDTLYGNANPMTAEDIAATLLWVANQPAHLNINTLELMPVSQSFA
GFQVAREG