Protein Info for GFF2988 in Sphingobium sp. HT1-2

Annotation: Kup system potassium uptake protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 632 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 58 to 80 (23 residues), see Phobius details amino acids 112 to 135 (24 residues), see Phobius details amino acids 145 to 168 (24 residues), see Phobius details amino acids 178 to 200 (23 residues), see Phobius details amino acids 224 to 244 (21 residues), see Phobius details amino acids 256 to 277 (22 residues), see Phobius details amino acids 298 to 323 (26 residues), see Phobius details amino acids 344 to 369 (26 residues), see Phobius details amino acids 375 to 397 (23 residues), see Phobius details amino acids 405 to 423 (19 residues), see Phobius details amino acids 435 to 453 (19 residues), see Phobius details PF02705: K_trans" amino acids 22 to 474 (453 residues), 623.8 bits, see alignment E=1.5e-191 PF22776: K_trans_C" amino acids 484 to 632 (149 residues), 178.1 bits, see alignment E=1e-56

Best Hits

Swiss-Prot: 62% identical to KUP2_SPHWW: Probable potassium transport system protein kup 2 (kup2) from Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)

KEGG orthology group: K03549, KUP system potassium uptake protein (inferred from 80% identity to sjp:SJA_C2-02570)

Predicted SEED Role

"Kup system potassium uptake protein" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (632 amino acids)

>GFF2988 Kup system potassium uptake protein (Sphingobium sp. HT1-2)
MTEQGDPAAGQDRTPHGRPAALALGALGVVFGDIGTSPLYALKESFVGHHPLAVDPLHIY
GVLSLIFWTMTLIVTVKYVFIVMRADNDGEGGSMALLALIGRRLGETRWTPAIAMLGVLA
TALFYGDAIITPAISVLSAVEGLTIVQASLADMVLPIAIVILIALFLIQRFGTAMVGMAF
GPIMAIYFVTLAALGIANIVQHPEIIGIVNPLWAIRFFAIDPRLAFLALGSVVLAVTGAE
ALYADMGHFGRKAISIAWLYAAFPCLMLNYLGQGALLLDNPAAAQNPFFLMAPDWARLPL
VILATMATIIASQAVISGAFSVTQQAVQLGFLPRLRILHTSASAAGQIYVPLINWLLLIF
VILLVLGFGNSSNLAAAYGIAVTGTMVITACMLGVLTFSVWRWPLPAAAGVTGLFLIIDG
AYFASNVTKIPDGGWFPLLVAAVVFTVLTTWATGRRIMRHYLREGAMELDLFVRSTLASL
KRVPGTAIFLSSTTDGVPPALLHNVKHNKVLHERVIILTVRTQGVPHLPLQGRTTVEDHG
SGFYRLILRHGFMEDVDIPAAMKSVHDCGGPISVKDTSYFLSRQTLIPSERPGMAMWREK
LFAWMIRNAESPMAFFNLPTNRVVELGSQIEI