Protein Info for GFF2982 in Xanthobacter sp. DMC5

Annotation: Sensor protein KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 905 transmembrane" amino acids 404 to 422 (19 residues), see Phobius details amino acids 428 to 444 (17 residues), see Phobius details amino acids 448 to 448 (1 residues), see Phobius details amino acids 451 to 474 (24 residues), see Phobius details amino acids 481 to 499 (19 residues), see Phobius details PF02702: KdpD" amino acids 25 to 233 (209 residues), 332.7 bits, see alignment E=2.4e-103 PF00582: Usp" amino acids 254 to 370 (117 residues), 33.3 bits, see alignment E=2.1e-11 PF13493: DUF4118" amino acids 406 to 511 (106 residues), 104.4 bits, see alignment E=8.3e-34 PF13492: GAF_3" amino acids 530 to 649 (120 residues), 69.9 bits, see alignment E=8.5e-23 PF00512: HisKA" amino acids 669 to 736 (68 residues), 57.7 bits, see alignment 2.9e-19 PF02518: HATPase_c" amino acids 781 to 895 (115 residues), 84.2 bits, see alignment E=2.7e-27

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 65% identity to mci:Mesci_1804)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (905 amino acids)

>GFF2982 Sensor protein KdpD (Xanthobacter sp. DMC5)
MPEERESDHRPSPDALLKEAQRESRGQLKIFLGAAPGVGKTYEMLASGRTRLKEGADVVI
GVVETHGRRETQALVEGFEIVPRRSVAYKGRQLQEMDLDAILARKPDLVLVDELAHTNAP
DSRHAKRYMDVEELLAAGIDVYSTLNIQHVESLNDVVAQITRIRVRETVPDAIIDRADEI
EVIDITPSDLIQRLHDGKVYVPDTARRAVDNYFSPGNLTALRELALRRTAQRVDEQLRSH
MRAHAISGPWAAGERVLVCISEDKRCAALVRYAKRLADRLRAPWVALYVETQRSFQLGDA
DRDRIAEVLRLAERLGAEAVTVPGGAHIADDVLAYARAANVTQIVIGKSDRSRWFEILHG
SVVHDLVRRSGNISVHVIAGDAGQPASEETCAAAPLPVRREVRAYAEGAFLVAAATLVGV
ALQRLLGLQNVALVFLTAVLVSAVRSGLWPALATSVAAMLAFNFFFIPPLYTFTIADPEN
VIALFFFLVVAAIASNLTARVRGQALAARARAKTTEDLYLFSKKLASAVSLDDLLWATAF
QIASMLKVRVVMLLPEDGALTVKAGYPPEDAIDAADLAAANWTYENNRPAGRGADTLPGA
RRLFLPMHTGRGAVGVVGIDKDKEGPPLSPEERRLLDALADQAALAVERANLVSDVEKAR
LDAETDRLRSALLTSISHDLKTPLASILGAAGTLRSFAASLTEDQRGEMLATIEEEAQRL
NRFIANLLDMTRLESGAIVPNTSPNDLAEIVGSAMRRAAAILKDHRVEIDLAPDLPMLNV
DPVLFEQALFNLLDNAAKYAPAGSLVSLHGWAENGPEGGHVTLQVLDEGPGIPAEDVDQV
FDKFFRARKQDQVRAGTGLGLAICRGFIEALGGTIAVANRADRSGAVFTIDLPARALAPM
LETTP