Protein Info for GFF2977 in Sphingobium sp. HT1-2

Annotation: RND efflux system, inner membrane transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1062 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 342 to 362 (21 residues), see Phobius details amino acids 369 to 391 (23 residues), see Phobius details amino acids 397 to 419 (23 residues), see Phobius details amino acids 440 to 465 (26 residues), see Phobius details amino acids 473 to 499 (27 residues), see Phobius details amino acids 551 to 569 (19 residues), see Phobius details amino acids 879 to 898 (20 residues), see Phobius details amino acids 905 to 926 (22 residues), see Phobius details amino acids 933 to 954 (22 residues), see Phobius details amino acids 983 to 1004 (22 residues), see Phobius details amino acids 1014 to 1039 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 3 to 1037 (1035 residues), 1095.3 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1047 (1045 residues), 1143.2 bits, see alignment E=0 PF03176: MMPL" amino acids 348 to 520 (173 residues), 31.9 bits, see alignment E=7.1e-12

Best Hits

KEGG orthology group: None (inferred from 53% identity to lpc:LPC_1637)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1062 amino acids)

>GFF2977 RND efflux system, inner membrane transporter (Sphingobium sp. HT1-2)
MRFSRFFIDRPIFAAVIAVVITVVGALAFVGLPVSQYPDIVPPTVTVSAQYPGASAETVA
STVAAPIEQEINGVDDMLYQSSQSTGDGKVVITVTFKIGTDLDAAQVLVQNRVAVAIPRL
PEEVQRLGVVTRKTTPEFLMVVNLQSPDGTYDRDYISNYALTQVRDRLARLDGVGDVQLF
GSRDYAMRIWIDPDRAAALDLTAGEIVSALRAQNVQVSAGSIGQPPYDRGEAFQLGVEMQ
GRLTTPDQFSDIVIRSDADGHQVRVRDVARVELGAQDYGTNTYLSNKPTVVIATMQRPGS
NALDAAEKVKAEMEQLSKRFPKGLEYSIIYNPTEFISQSIDAVYHTLFEAVILVVIVILI
FLQNWRAAVIPIIAIPVSLIGTATMLAAVGYSLNNLSLFGLVLAIGIVVDDAIVVVENVE
RNIENGMSPLQAARVSMDEVSTALIAIVLVLCAVFVPTLFITGISGAFYQQFAVTISTAT
VISLILSLTLSPAAAALLLKSKHGAHDLDNAPRWRQVAAKAADRFNQGFDRMSAGYARLT
RFLVARPKKMLLTYAGLIAATIALFWVTPGGFIPAQDQGYFLAVVQLPSGASLERTDKVT
REVAAKILPIKGLRGAVMFAGFHGPSQTQAPNSAAIYFPFKSFAERKAEGATYAGIMDQA
NKAVAGYDKARILLVPPPLIQGIGSAGGYRLMLEDREDRGYAELNKVAGELIGKANQSPS
LAQVYTLFDVGTPRIFADVDRRKADLLGVPPERVFEAMQVYLGSAFVNDFNLLGRTYRVT
AQADAEHRGTVADIANLKTRSNSGQMVPIGSVSTFRDKTGPYRVVRYNLLPAVEIDGDTA
PGYSSGQSLSTMEKLADAAPAGYASEWTGVAYQQISAGNTAGIVFGMAVFFVFLVLAAQY
ESLTLPLSIILIVPMCLFAAMLGVNLRGMDNNILTQIGLVVLIALAAKNAILVVEFAKQA
EEEQGLSPVEAAVQAAQTRLRPILMTSFAFILGAVPLVIASGAGAELRQALGTAVFFGMT
GVTAFGLLFTPTFYVVCRALGDRFARRRRPEADDAAALQPAE