Protein Info for GFF2917 in Xanthobacter sp. DMC5

Annotation: Hca operon transcriptional activator HcaR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 297 transmembrane" amino acids 231 to 249 (19 residues), see Phobius details PF00126: HTH_1" amino acids 5 to 64 (60 residues), 76.8 bits, see alignment E=1e-25 PF03466: LysR_substrate" amino acids 89 to 293 (205 residues), 128.2 bits, see alignment E=2.9e-41

Best Hits

Swiss-Prot: 38% identical to ALSR_BACSU: HTH-type transcriptional regulator AlsR (alsR) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 85% identity to xau:Xaut_0855)

Predicted SEED Role

"Chromosome initiation inhibitor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (297 amino acids)

>GFF2917 Hca operon transcriptional activator HcaR (Xanthobacter sp. DMC5)
MRFDLRHVRCFVLLAEELHFGRAAQRAHMTQPGMSRLIRDLEQDVGVPLFARTTRTVVLT
EAGKAFLAESREALARVERAVSRARRTAGGEVGVLRIGYMDFAINGRLPEFLNSFSRYRP
EIRLELSFTPTLQQQEALLAERIDIGFMIGPFEEAGMESYAFDDNRYVALLPITHPLSNV
RVLRLADLADQPFVLGSGENWGAFRTAFFAVCHRAGFTPRIVQEASSSEGIFGLVAAGAG
VSVYASCVRNLQRRGIVIRDLDDVADKLVTCAAWATPIRAPAVTVFTEYMRRVWGGT