Protein Info for GFF2902 in Variovorax sp. SCN45

Annotation: ABC transporter, substrate-binding protein (cluster 13, osmolytes) / ABC transporter, permease protein (cluster 13, osmolytes)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 508 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 316 to 339 (24 residues), see Phobius details amino acids 353 to 388 (36 residues), see Phobius details amino acids 423 to 453 (31 residues), see Phobius details amino acids 473 to 495 (23 residues), see Phobius details PF04069: OpuAC" amino acids 30 to 286 (257 residues), 182.6 bits, see alignment E=1.1e-57 PF00528: BPD_transp_1" amino acids 326 to 500 (175 residues), 79.9 bits, see alignment E=2e-26

Best Hits

KEGG orthology group: K05846, osmoprotectant transport system permease protein (inferred from 90% identity to vpe:Varpa_1906)

Predicted SEED Role

"L-proline glycine betaine binding ABC transporter protein ProX (TC 3.A.1.12.1) / Osmotic adaptation" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (508 amino acids)

>GFF2902 ABC transporter, substrate-binding protein (cluster 13, osmolytes) / ABC transporter, permease protein (cluster 13, osmolytes) (Variovorax sp. SCN45)
MHLPRCLHRLALLLTLAWLAMAPAAHAADDTLRVGSKRFTESYILAELLAQTAAPHTASP
PVVRQGLGNTAIVYEALRSGAIDLYAEYTGTIAQEILKGSPAESREAMNAALAPMGLGVA
IPLGFNDGYALAVRAADADRLGLRTLSDLAKHPELKLGLSNEFIGRADGWKGLAERYGFK
QTPTGLDHGLAYDAIAAKQIDAIDIYTTDAKIDHLGLRVLEDDRKYFPRYDAVVLYKLDL
PQRLPEAWAALKTLEGKVDEHAMIAMNARAELQSVPFDAIARDFLAGAGKEAKEARRGFT
AKLFGPDLWKLARQHLFLVALSVGIAILIGVPIAILVFPHVRLRAVVLGFASLLQTVPSL
ALLAVLISMLGAIGALPALIALTLYSLLPIMRNTVTGLAEVPNGLRLAGTALGMTPPQSL
RLVLLPLALPTLLAGVRTATAIAIGTATIAAFIGAGGFGERIVTGLALNDRELLLAGALP
AAALALVSEGVFELIEFLMRRGRRVSLD