Protein Info for GFF2897 in Xanthobacter sp. DMC5

Annotation: Deacetylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01979: Amidohydro_1
  • amino acids 58 to 379 (322 residues), 54.8 bits, E=9.8e-19
• PF07969: Amidohydro_3
  • amino acids 339 to 384 (46 residues), 38 bits, 1.5e-13

Best Hits

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 92% identity to xau:Xaut_0650)

Predicted SEED Role

"Metallo-dependent hydrolases, subgroup B"

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• UMP biosynthesis I (5/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Protein Sequence (425 amino acids)

>GFF2897 Deacetylase (Xanthobacter sp. DMC5)
MAEPAGYDILLKGGHVICPATGINGIRDVAVRDGRIAAVEETILPSSATETIDVSGKLVL
PGMIDTHGHIYQYVTGRFGLNPDMVGVHSGVTTVIDQGGPSCMTLPGFRKFIAEPSDTRI
YAFLSAYLVGGLEGHYYPNLYSPDCVDIEATVRSAIANRDLVRGIKGHAEIGGFARWGIR
VMEMAAEIARRAEIPLYVHFGTLWGLPESGANGEDADTILERVIPLLKEGDVLAHPFTRH
PGGFVNQKGEVHHVIQAALDRGLKVDVGHGSHFSYRLAKKAIAAGVVPHTLGADMHGYNT
HVPAPAGTPEEHYDDENHPFKGQARFSLTQAMSSMMALGLSLEQVVPMVTINPAKMIGLT
DRVGSLTVGYAADISVLDDNRGRFLLRDNEDTKVVAERLLTPAFCLRAGKKFDADAVILP
QAVAA