Protein Info for GFF289 in Variovorax sp. SCN45

Annotation: Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 281 PF00899: ThiF" amino acids 37 to 264 (228 residues), 133.5 bits, see alignment E=3.3e-43

Best Hits

KEGG orthology group: None (inferred from 89% identity to vpe:Varpa_2720)

Predicted SEED Role

"Probable HesA/MoeB/ThiF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (281 amino acids)

>GFF289 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 (Variovorax sp. SCN45)
LSAIITAGITTPLAAADVAIDTAAPDYARRFGGLERLYGVAGAARIRNAHVLVVGIGGVG
SWAVEALARSGVGRLTLVDLDHVSESNINRQIHALDATVGQAKVEAMRDRIAQINPECKV
LAVDEFVEPGNWTTVLETAQTANGPVTAVVDACDQVKAKLTMAAWARASRAAFVTVGAAG
GKRQAHKVDIDDLSLVTHDPLLAQLRQRLRKEHGAPREGRKIGVTCVFSRESVAPPDASC
AIEGDGSLNCHGYGSVVSVTATFGQCAAGWVLDKIASNLAL