Protein Info for GFF2888 in Sphingobium sp. HT1-2

Annotation: TldD family protein, Actinobacterial subgroup

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 544 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF01523: PmbA_TldD_1st" amino acids 60 to 124 (65 residues), 54.8 bits, see alignment E=1.3e-18 PF19290: PmbA_TldD_2nd" amino acids 159 to 239 (81 residues), 21.7 bits, see alignment E=3.6e-08 PF19289: PmbA_TldD_3rd" amino acids 289 to 536 (248 residues), 97.2 bits, see alignment E=1.3e-31

Best Hits

KEGG orthology group: K03568, TldD protein (inferred from 81% identity to xcv:XCV0092)

Predicted SEED Role

"TldD family protein, Actinobacterial subgroup" in subsystem Putative TldE-TldD proteolytic complex

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (544 amino acids)

>GFF2888 TldD family protein, Actinobacterial subgroup (Sphingobium sp. HT1-2)
LHRRDFLAFGTMGVGGLVLPSFFGKVIAAEDLNSALDVGFKKGLADAAMNAAKSAGASCC
DVRVGRYLRQFVITREKNVENIVNTESTGVGIRVLANGAWGFAATNELSKEAVAKAAQQA
VAIAKANAPQQSAPVQLAPVNGAGEVSWKTPIVKNSMAVPIKDKVDLLMGVNAAAMEAGA
DFVNSILFLVNEQKYFASTDGSYIDQDVHRIWAPMTVTAVDKTSGKFRTREGLSSPMGLG
FEYLDGAASGKTVLPNGVTVYGNSYDMKEDAIAAAKQARAKLKAPSVKPGKYDLVLDPSH
TWLTIHESVGHPLELDRVLGYEANYAGTSFATMDKLQAHFQYGSDKVNIVADKVQPGSLG
AVAYDDEGVKTKKWDLIRDGKLVGYQAIRDQAHIEGKKESDGCAYADSWSNVQFQRMANV
SLEPGKTKQSVADMIAGVEDGIYIIGDGSFSIDQQRYNAQFGGQLFYEIKNGKITQQIED
VAYQIRTPEFWNACVGVCDQSDYRLGGSFFDGKGQPAQVSAVSHGSSTARFNGINVINTA
RSLG