Protein Info for GFF2874 in Sphingobium sp. HT1-2

Annotation: Ferrichrome-iron receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 689 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF07715: Plug" amino acids 54 to 152 (99 residues), 62.9 bits, see alignment E=3.7e-21 TIGR01783: TonB-dependent siderophore receptor" amino acids 56 to 689 (634 residues), 259.8 bits, see alignment E=3.1e-81 PF00593: TonB_dep_Rec_b-barrel" amino acids 224 to 658 (435 residues), 138.3 bits, see alignment E=7e-44

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 77% identity to sal:Sala_0947)

Predicted SEED Role

"Ferrichrome-iron receptor" in subsystem Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (689 amino acids)

>GFF2874 Ferrichrome-iron receptor (Sphingobium sp. HT1-2)
MKKFIALSGAALIALCHGTAWSAEAAAADAPRTDEDSIVVTAATTGSKTDTALVELPQPI
KVITSEQYLSQGAISISDTVKYAAGVLANPYGRDTRVDGFNVRGLDALQFRDGMRDIFSY
YASITSDPYNFSRVEILRGPASVLFGQGSIGGLVNLVSKTPDFTTRGELNLVYGSYDRKE
AMGDVNVALADNLAVRFVGRVRDADTYVDHVPDDRVMFAPSIRWQPTPDTDIVLTGLYQE
DDTGSTSQFLPIVGTFMPNNVAGEQLDRYTFVGKAGWDRYDGRSLQGGGSITHRFSDNVK
LSLKARYIDSDLEYNTHYADSYTNPQDPFSVYGTDGRTIALTADASDARMNVFSTDNNVQ
FNFNTGANIEHKLLVGIDYSWNKVSKRYAGGYELVDLYDIDYDALATYDPTGPFTSDSQK
QLGVYVQDQIRFYDRVSVVLGARRDRVTGSSGQKDNATTFRAGIIGEIGAGISPFFSYTE
SFLPVAGRIDNGDGSYGDAYKPQTGTQYEAGVKWQPAPSTLVTATVFKIKERNRVLYLAA
GGTEQSGVLNTKGFEIEASHTLPGNFELLANYGYSKLKSETNTSLDYMPRHTASLWSTKT
FGLADEAQLRLGGGVVYSGKSVSTSAIWSIVTPSRTTVDALAEITWQDWRFALNATNLLN
KKFYASCLARGDCFMGAPRNVMGTVGFRF