Protein Info for GFF2865 in Variovorax sp. SCN45

Annotation: Uncharacterized MFS-type transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 509 transmembrane" amino acids 15 to 39 (25 residues), see Phobius details amino acids 52 to 71 (20 residues), see Phobius details amino acids 83 to 104 (22 residues), see Phobius details amino acids 112 to 132 (21 residues), see Phobius details amino acids 142 to 164 (23 residues), see Phobius details amino acids 170 to 191 (22 residues), see Phobius details amino acids 202 to 224 (23 residues), see Phobius details amino acids 232 to 252 (21 residues), see Phobius details amino acids 273 to 296 (24 residues), see Phobius details amino acids 308 to 327 (20 residues), see Phobius details amino acids 336 to 355 (20 residues), see Phobius details amino acids 363 to 388 (26 residues), see Phobius details amino acids 408 to 427 (20 residues), see Phobius details amino acids 475 to 498 (24 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 16 to 437 (422 residues), 249.1 bits, see alignment E=4.2e-78 PF07690: MFS_1" amino acids 22 to 413 (392 residues), 168.4 bits, see alignment E=1.1e-53

Best Hits

Swiss-Prot: 31% identical to EFPA_MYCTO: Uncharacterized MFS-type transporter EfpA (efpA) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 67% identity to axy:AXYL_04283)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (509 amino acids)

>GFF2865 Uncharacterized MFS-type transporter (Variovorax sp. SCN45)
MDSHIPAAADPRRRLALVAAVYLGSFIATLDVSIVNVALPTLQRALSTDLAGLQWVIDIY
ALCLSAFMLSAGPLGDSYGRKRAWLAGVIVFTLGSAMCALAGNLPTLLAGRAVQGVAGAL
LIPGALSLLAHAFPEPASRARVIGGWSSFTALSLILGPMLGGLLVDHAGWQSIFLINLPI
GVLTVGLGLWGIRETAHPEHAALDPVGQVLSVLWLGALTYGLIVAGEHGWGSVQAASALV
AAAVGLVLFLVVEARVARPLLPLGLFRDARFSVTNFASFVLGFSSYASLFFFSLFLQQVQ
GWSPSDTGWRLVPQFVATGVVASQFGRLARRFDVHTLMVAGYTLIGGSMLLLTLFSADTP
YAPMALLFLFLGAGAGLAVPATSTAVMASVPAQRSGMASATMNALRQAGMLIGIALLGTL
MSTRATSLLADSLEHAGLSGARQAAVDAVSRHDLHALSSLDAGIAHELLATALAGGFHAA
MACAGVAGLLAAGLLLSVRPRAAAVAARA