Protein Info for PS417_14545 in Pseudomonas simiae WCS417

Annotation: amino acid transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 transmembrane" amino acids 21 to 39 (19 residues), see Phobius details amino acids 43 to 66 (24 residues), see Phobius details amino acids 102 to 124 (23 residues), see Phobius details amino acids 131 to 152 (22 residues), see Phobius details amino acids 160 to 183 (24 residues), see Phobius details amino acids 205 to 227 (23 residues), see Phobius details amino acids 248 to 269 (22 residues), see Phobius details amino acids 281 to 303 (23 residues), see Phobius details amino acids 339 to 360 (22 residues), see Phobius details amino acids 366 to 391 (26 residues), see Phobius details amino acids 410 to 429 (20 residues), see Phobius details amino acids 435 to 454 (20 residues), see Phobius details PF00324: AA_permease" amino acids 22 to 455 (434 residues), 337.2 bits, see alignment E=1.6e-104 PF13520: AA_permease_2" amino acids 25 to 434 (410 residues), 129.2 bits, see alignment E=2.1e-41

Best Hits

Swiss-Prot: 59% identical to CYCA_ECOLI: D-serine/D-alanine/glycine transporter (cycA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 96% identity to pfs:PFLU3375)

MetaCyc: 59% identical to D-serine/alanine/glycine:H+symporter (Escherichia coli K-12 substr. MG1655)
RXN0-5130; RXN0-5201; RXN0-5202; RXN0-5203; TRANS-RXN-62A; TRANS-RXN-62B

Predicted SEED Role

"D-serine/D-alanine/glycine transporter" in subsystem Glycine and Serine Utilization or Pyruvate Alanine Serine Interconversions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UCH2 at UniProt or InterPro

Protein Sequence (465 amino acids)

>PS417_14545 amino acid transporter (Pseudomonas simiae WCS417)
MKTTTSGLYEKPALQRTLSNRHIQLMAMGGAIGTGLFMGSGKIIALSGTSIILIYMIIGL
FVYFVMRAMGELLLSNLNFKSFADFAGAYLGPRAAFFLGWSYWLSWSVAVIGDAVVVGGF
FQYWFPHVPAWMPAVGMLLTLFALNVLTVRLFGEVEFWFAIIKLIAVLTLIGVSGVLIAS
SFVSPTGVTASFTHLLDPQAAFPNGLFGFFAGFQMAIFSFAGTELIGTAAAETRAPEKTL
PKAINSIPLRIILFYVLALACIIAVTSWQHVSPSKSPFVELFLVAGFPAAAGIVNFVVLT
SAASSANSGVFSASRMLFGLADLGDAPGIFRRLSKSSVPFISLAFTTLLMLLGLVLLFVV
PEVMTAFTIVSTVSAILVIFTWSTILASYIAYRKKRPDLHAKSLYKMPGGVLMAWFSLAF
LAFVLGLLALRPDTRLALCVMPAWFIWLWIAYPFSRFQGASLVKT