Protein Info for GFF2804 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: D-amino acid dehydrogenase small subunit (EC 1.4.99.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF00070: Pyr_redox" amino acids 2 to 36 (35 residues), 23.8 bits, see alignment 2.1e-08 PF01266: DAO" amino acids 2 to 396 (395 residues), 280.5 bits, see alignment E=1.1e-86 PF00890: FAD_binding_2" amino acids 3 to 257 (255 residues), 23.1 bits, see alignment E=1.6e-08 PF02558: ApbA" amino acids 3 to 38 (36 residues), 24.8 bits, see alignment 6.1e-09 PF13450: NAD_binding_8" amino acids 5 to 36 (32 residues), 26.8 bits, see alignment (E = 2e-09) PF01593: Amino_oxidase" amino acids 202 to 255 (54 residues), 20.6 bits, see alignment 1e-07

Best Hits

Swiss-Prot: 100% identical to DADA_SALTY: D-amino acid dehydrogenase (dadA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K00285, D-amino-acid dehydrogenase [EC: 1.4.99.1] (inferred from 100% identity to set:SEN1234)

MetaCyc: 90% identical to D-amino acid dehydrogenase (Escherichia coli K-12 substr. MG1655)
RXN-11193 [EC: 1.4.5.1]; 1.4.5.- [EC: 1.4.5.1]

Predicted SEED Role

"D-amino acid dehydrogenase small subunit (EC 1.4.99.1)" in subsystem Pyruvate Alanine Serine Interconversions or Respiratory dehydrogenases 1 (EC 1.4.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.5.1 or 1.4.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (432 amino acids)

>GFF2804 D-amino acid dehydrogenase small subunit (EC 1.4.99.1) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MRVVILGSGVVGVTSAWYLSQAGHDVTVIDRESGPAQETSAANAGQISPGYAAPWAAPGV
PLKAIKWMFQRHAPLAVRLDGTPFQLKWMWQMLRNCDTRHYMENKGRMVRLAEYSRDCLK
TLRAATGIEYEGRQGGTLQLFRTAQQYENATRDIAVLEDAGVPYQLLESSRLAEVEPALA
EVAHKLTGGLRLPNDETGDCQLFTQRLARMAEQAGVTFRFNTPVEKLLYENDQIYGVKCA
DEIIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIVEPDGAPVSTILDETYKIA
ITRFDKRIRVGGMAEIVGFNTDLLQPRRETLEMVVRDLFPRGGHIEQATFWTGLRPMTPD
GTPVVGRTRYKNLWLNTGHGTLGWTMACGSGQLLSDILSGRTPAIPYDDLSVARYRSDFT
PTPPQRLHSAHN