Protein Info for GFF2797 in Sphingobium sp. HT1-2

Annotation: Two-component system sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 transmembrane" amino acids 12 to 39 (28 residues), see Phobius details amino acids 164 to 186 (23 residues), see Phobius details PF00672: HAMP" amino acids 184 to 234 (51 residues), 47.4 bits, see alignment 1.9e-16 PF02518: HATPase_c" amino acids 337 to 442 (106 residues), 89.4 bits, see alignment E=2.2e-29

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (443 amino acids)

>GFF2797 Two-component system sensor histidine kinase (Sphingobium sp. HT1-2)
MKAGFLRWANSIHAHLLALALVVILTLTAFSLTLLLYFIPPERMPLSVYEIARIVHGQPL
LRDEPVVHEVRQAAAPPASTDPAERLIAALLAQRLSLPASDVRIRLDPGDRERIGQFVAE
MQLYGPDGVADPFILGTFTAAIRQPDGEWRMITREARGGRSLWRLLGQYAFLVGILLVVP
LSLWFSARLTRPIRAFAASAERMGAGQEEQPIPLDGPSEIRLAAQSINEMQARIARYVRE
RTSVVGAIAHDLRTPLSRLHFHLTAAPAPVRIAAEEEIRQMEALIGTTLDFVDNENRPRL
KEPLDLGLLVEGLVDDFADMGRDVILTGAEPVIIAGDMILLKRLFTNLIDNAIKYGDRAR
VRVMRDEGRAIVTIEDDGPGMEQADIARAFEPFYRGEPSRNRSTGGVGLGLSIVQSAAQA
HQGRVSLARAPDGGLRAQVELPV