Protein Info for GFF2777 in Xanthobacter sp. DMC5

Annotation: Proline/betaine transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 441 transmembrane" amino acids 27 to 49 (23 residues), see Phobius details amino acids 59 to 78 (20 residues), see Phobius details amino acids 97 to 116 (20 residues), see Phobius details amino acids 121 to 142 (22 residues), see Phobius details amino acids 164 to 186 (23 residues), see Phobius details amino acids 198 to 217 (20 residues), see Phobius details amino acids 250 to 269 (20 residues), see Phobius details amino acids 287 to 307 (21 residues), see Phobius details amino acids 317 to 336 (20 residues), see Phobius details amino acids 342 to 367 (26 residues), see Phobius details amino acids 382 to 404 (23 residues), see Phobius details amino acids 411 to 430 (20 residues), see Phobius details PF00083: Sugar_tr" amino acids 30 to 234 (205 residues), 74.2 bits, see alignment E=1e-24 amino acids 236 to 437 (202 residues), 46.6 bits, see alignment E=2.4e-16 PF07690: MFS_1" amino acids 31 to 381 (351 residues), 108.6 bits, see alignment E=3.3e-35 amino acids 270 to 437 (168 residues), 51.6 bits, see alignment E=7.1e-18

Best Hits

KEGG orthology group: K03762, MFS transporter, MHS family, proline/betaine transporter (inferred from 72% identity to pap:PSPA7_3026)

Predicted SEED Role

"L-Proline/Glycine betaine transporter ProP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (441 amino acids)

>GFF2777 Proline/betaine transporter (Xanthobacter sp. DMC5)
VSTLDLAQTRPHAPSEGGQKIDMKKRAVAVGIGNFMEWFDFAIYGYFAATIGQTFFPSAA
PGVSLLSSLAVFAVGFLSRPLGAVVLGPVGDRMGRRAVLIITVFGMGLVTTLIGLLPGYA
AIGIAAPILLIVLRFLQGMMVGGEWSSAGIYIVESAPSHRRATAASVITGTAGIAFLTGT
ALAATLSATLTPAELASWGWRLPFIASIIMAAVAMYIRRKLSDTPVYVELEHRRATGNVQ
EVARGEKVRAFILSFAFASLFGVSLYYFITYANNHLTQTVGLSKSSSLWLCSIALVIYTI
SHPIIGLLSDRVGRRRLLLFAAGGLTLLAYPIFLMMNTGSTALILTALAILAILVAITAV
MDVVLLVEVFPASIRSTGAAVGHNVALAVLAGPGPFLAAALISMTGDPNIPAWYLAGVSL
ACFLVLWFMLPETRDKDITQG