Protein Info for GFF2773 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01259: SAICAR_synt
  • amino acids 16 to 266 (251 residues), 252.6 bits, E=2.1e-79
• TIGR00081: phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • amino acids 16 to 300 (285 residues), 261.2 bits, E=5.7e-82

Best Hits

Swiss-Prot: 83% identical to PUR7_RHOFT: Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC) from Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)

KEGG orthology group: K01923, phosphoribosylaminoimidazole-succinocarboxamide synthase [EC: 6.3.2.6] (inferred from 84% identity to adn:Alide_4126)

Predicted SEED Role

"Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)" in subsystem De Novo Purine Biosynthesis (EC 6.3.2.6)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.6

Protein Sequence (302 amino acids)

>GFF2773 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTSALHTSALTSLPLLARGKVRDNYAVGDDRILMVASDRISAFDVIMGEPIPGKGELLTR
LSLFWFDQLGPKGLAICPIHLTGEAPESVVSPAEVPQVTGRSMLVQRLKPIPVEAVVRGY
LAGSGWKEYQESRSVCGVKLPEGLQNASQLPEPIYTPAAKAAMGEHDENITFERTVEMIG
PELAAQIRDVSIALYKAAAAIALKKGIIIADTKFEFGLDKAGKLVLMDEVLTPDSSRYWP
AESYVVGQNPPSYDKQFLRDWLETAQVGGKPWDKTPPAPRLPREVIEKTAAKYQEALTRL
MG