Protein Info for GFF2768 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 515 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details PF02113: Peptidase_S13" amino acids 56 to 359 (304 residues), 179.9 bits, see alignment E=4e-57 amino acids 371 to 511 (141 residues), 83.7 bits, see alignment E=6.2e-28 TIGR00666: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase" amino acids 77 to 343 (267 residues), 128 bits, see alignment E=1.9e-41

Best Hits

Predicted SEED Role

"D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4)" in subsystem Peptidoglycan Biosynthesis (EC 3.4.16.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.16.4

Use Curated BLAST to search for 3.4.16.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (515 amino acids)

>GFF2768 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MLDTEFFRRATPLRRARGLALCLLAGLTLPACAQMAGRGDPLPPAVLAAMSRAQVPASAL
SALVISVDPDAHERLRHRAGTPVNPASVMKLVTTYAAIDLLGSDFTWNTRFYTDGSVENG
VLRGNLYVRGGGDPKFVLERIQEAYLALQAKGVRVILGDMVLDHSAFELPAIDPGAFDGE
ALRPYNATPDALLVNFKSVILTFQPDLANGVARVLSEPPMAGLAVDATVPLSRGTACGDW
RSTVQARFDDPNSIRFEGRYPQVCGELKWPVAYQQPASYAARAMEGLWRASGGSITGQVR
DGTMPAEVQLLHEARSLPLSEVIVDVNQWSNNVMAQQVFLTLGQLAPPQTATPALAAVAR
GSAADRLVPSRPARFEYSREVVTDWWKRTFGPRVPGPVLDNGSGLSRDERITPEALAGLL
RHAARHPQGVQFVQSLSIAGVSGTAARLARGGQSAARGNAWVKTGTLRDVTGIAGYVNAS
NGARYVVVGFINHPNAAAARPALDALLEWTALLPD