Protein Info for GFF270 in Xanthobacter sp. DMC5

Annotation: Acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 22 to 134 (113 residues), 138.3 bits, E=2.9e-44
• PF02770: Acyl-CoA_dh_M
  • amino acids 138 to 231 (94 residues), 83.6 bits, E=1.8e-27
• PF00441: Acyl-CoA_dh_1
  • amino acids 250 to 390 (141 residues), 103.8 bits, E=2e-33
• PF08028: Acyl-CoA_dh_2
  • amino acids 258 to 378 (121 residues), 27.6 bits, E=6.2e-10

Best Hits

Swiss-Prot: 67% identical to GCDH_HUMAN: Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) from Homo sapiens

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 92% identity to xau:Xaut_4712)

MetaCyc: 68% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (4/15 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (5/17 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (4/16 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Protein Sequence (397 amino acids)

>GFF270 Acyl-CoA dehydrogenase (Xanthobacter sp. DMC5)
MAASGKPIFDWADPFDINSQLTEDERLVRDTARDYAQEKLLPRVTSAYLDERFDREIMNE
MGELGLLGPTIPAEYGGAGLGYVAYGLAAREVERVDSGYRSAMSVQSSLVMHPIYAYGTE
EQRKKYLPKLATGEWVGCFGLTEPDAGSDPAGMRTRAEKIDGGYRLNGAKMWITNSPISD
LAVVWAKSAAHDNAIKGFVVERGMKGFSTPKIEGKLSLRASITGEVVLEDVEIPEENLLP
NAAGLPGPFGCLNRARYGIGWGAMGAAEACYAAARQYTLDRKQFGRPLAATQLVQKKLAD
MATEIALGLQLALRAGRMFDEGQLPIEAISFLKRNNCGKALDIARVARDMHGGNGISAEF
HVIRHAANLETVNTYEGTHDIHALILGRAITGIQAFF