Protein Info for PS417_13770 in Pseudomonas simiae WCS417

Annotation: major facilitator transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 402 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 42 to 63 (22 residues), see Phobius details amino acids 75 to 93 (19 residues), see Phobius details amino acids 99 to 120 (22 residues), see Phobius details amino acids 132 to 158 (27 residues), see Phobius details amino acids 163 to 182 (20 residues), see Phobius details amino acids 211 to 236 (26 residues), see Phobius details amino acids 248 to 267 (20 residues), see Phobius details amino acids 278 to 299 (22 residues), see Phobius details amino acids 305 to 329 (25 residues), see Phobius details amino acids 340 to 361 (22 residues), see Phobius details amino acids 367 to 388 (22 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 7 to 384 (378 residues), 301.6 bits, see alignment E=5.7e-94 PF07690: MFS_1" amino acids 13 to 354 (342 residues), 155.3 bits, see alignment E=3.2e-49 PF00083: Sugar_tr" amino acids 44 to 185 (142 residues), 27.4 bits, see alignment E=2.4e-10

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 96% identity to pfs:PFLU3046)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UI06 at UniProt or InterPro

Protein Sequence (402 amino acids)

>PS417_13770 major facilitator transporter (Pseudomonas simiae WCS417)
MSRRIAHLALLLGLITAVGPFAIDIYLPALPTLGASLHASPALVQMSLTVFFVIVGVCQL
FYGPISDVFGRKPPIYAGLVIFAVASVGCALAPTIETLIAFRALQAFGACAGMVIPRAIV
RDLYTGHEAAKLMALLMLVMSVSPILAPLAGSLVIALWSWREVFAVLAVVAVACLVMTIV
QLPETHPAERRLGKTLGNAFSSYGALLRDPVFIGLSVVCGFGLATFFVFIGSAPFVYIEY
YGLTPTQFSLGFALNAASFFAMSQLTARLTARFGLAPLIRWSVVAVAAVMALLAATTLWV
DSLALMMTLLFIGFGFLGLLLPAAGVLSLEDHGAVAGSASALLGAIQMITAALSMTVVGV
FADHTPAPMLIGIALCAIAAMLTTLWTLRRLPIHLASAPPSS