Protein Info for GFF2689 in Sphingobium sp. HT1-2

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1078 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 371 to 411 (41 residues), see Phobius details amino acids 419 to 438 (20 residues), see Phobius details amino acids 477 to 496 (20 residues), see Phobius details amino acids 506 to 531 (26 residues), see Phobius details amino acids 562 to 583 (22 residues), see Phobius details amino acids 901 to 922 (22 residues), see Phobius details amino acids 928 to 948 (21 residues), see Phobius details amino acids 954 to 974 (21 residues), see Phobius details amino acids 1004 to 1023 (20 residues), see Phobius details amino acids 1032 to 1057 (26 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1068 (1068 residues), 1468.1 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1054 (1049 residues), 904.8 bits, see alignment E=3.5e-276

Best Hits

Swiss-Prot: 61% identical to NCCA_ALCXX: Nickel-cobalt-cadmium resistance protein NccA (nccA) from Alcaligenes xylosoxydans xylosoxydans

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 64% identity to cak:Caul_2297)

MetaCyc: 52% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1078 amino acids)

>GFF2689 CzcABC family efflux RND transporter, transmembrane protein (Sphingobium sp. HT1-2)
MIARILSLSVRMRWAVLFLTLAIVGFGGWQITKLPIDAVPDITNRQVQVNTFNPTLGPVD
MEKQVTYPVETALAGIPGLTMTRSLTRNGFSQVTAIFTDSTDIFFARQQVTERLAQAKDS
LPSGVQPNLAPLSTGLGEIFFYSVAFRHPDGKNVKIVNGQPGWQSDGSYLTPEGERLTTE
LAKAAYLRTVQDWIIRPQMRNVKGVAGVDSNGGFVKQYLVQPNLNALATYGLSVTELADA
LQRANLSAGSNYIKRAGESFLVRADARLKSIEEIEEAVVATRAGVPVRVRDVGEVVIGGA
VRTGSGSRMGSEAVISTVLMLVGDNSRIVAMSAAEKLTQINKGLPPDVFAEPVYNRSKLV
NATISTVEKNLTEGALLVIVVLFLLLGNIRAALITAAVIPVTMLMTASGMNAIGESGNLM
SLGALDFGLIVDGAVIIVENALRRLAERQEHEGRLLTLSERLGETTEAAVEMVRPTVYGQ
LIIFLVFVPLLTFQGVEGKTFSPMAVTLMIALASAFILSITFIPAMIAIVIKGKVCETEV
KPIRWFKEKYEPLLKKAVARPLPFIAAGGGMFLAAVLCFGLLGEEFMPQLDEKDITVTNF
RVPSASIDQSTEMQLRIENTLKTLPEVALVFSKNGNADLGTDPMPPNASDTYVIPKPESE
WPSDVKSKDDILKRIEARMKPLIGNRTEIQQPIQMRFNELIAGVRADVAIKLYGDDLDQM
SQQAQRIAAVVRKIPGAGDVSAEQTSGAPTFDVQIDRLAVARYGLSVEEVANTVAAALGG
REAGLLFEGDRRFSVVVRLPDAQRDDLETLGSIPVMLPTPEGQVARSIPLREVARFSFTS
GLNQISRENGKRMVIVQINVRGRDLGGFVTEAQQKVGELQLPAGMYTDWGGTFESLQSAR
LRLLIVVPICFAAIFALLYMALGGAIPAAIVFSAVPMALAGGVFALLLRGIPFSITAAVG
FIALSGVAVLNGLVMMSAIRKYREDGAEEDQAIIGGAMERVRPVLMTALVASLGFVPMAL
ATGTGAEVQRPLATVVIGGLITSTALTLLVLPAITAFMGRLKKKQAQESSGNSEPATA