Protein Info for GFF2669 in Xanthobacter sp. DMC5

Annotation: NADH dehydrogenase-like protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07992: Pyr_redox_2
  • amino acids 10 to 325 (316 residues), 156.8 bits, E=2.1e-49
• PF00070: Pyr_redox
  • amino acids 164 to 245 (82 residues), 34.2 bits, E=7.3e-12
• PF22366: NDH2_C
  • amino acids 349 to 405 (57 residues), 34.6 bits, 4.3e-12

Best Hits

KEGG orthology group: K03885, NADH dehydrogenase [EC: 1.6.99.3] (inferred from 68% identity to azc:AZC_0804)

Predicted SEED Role

"NADH dehydrogenase (EC 1.6.99.3)" in subsystem Carboxysome or Respiratory dehydrogenases 1 (EC 1.6.99.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• NADH to cytochrome bd oxidase electron transfer I (2/2 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.99.3

Use Curated BLAST to search for 1.6.99.3

Protein Sequence (431 amino acids)

>GFF2669 NADH dehydrogenase-like protein (Xanthobacter sp. DMC5)
MAEAKESRPRIVIVGGGFGGLETAKGLAGADADVVLVDRENHHCFQPLLYQVATAALSPA
DVAWPVRGILSRQPNVTVLMAEVTDVDLPGRTVIAGGRRIVYDRLVLATGVTHSYFAHPE
WESVAPGLKRIEDATDIRRRILIAFEKAELTQDDAERQRLMTFIVVGGGPTGVELAGALH
ELARLAMPLDFRRIDPREARIVLLEAGPRILPALPESLSAYARHILERMGIDVRTGAAVT
RCDEAGVDLDAARIEGATILWAAGVVASPAARWLGTDADRAGRVRVEPDLTVPRHPEVFV
IGDTASVMAGERPVPGIAPAAKQMGRYVAQVIRARLAGQASPAPFRYRHQGDLATIGRKA
AVVKVGRTELKGFAGWLFWSVVHIYFLVSARNRIAVSFAWMWNYLTFQRSARLITLEHRR
SGAGEGPPGGP