Protein Info for GFF2665 in Xanthobacter sp. DMC5
Annotation: Gluconate 2-dehydrogenase flavoprotein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 45% identical to GADH1_PANCY: Gluconate 2-dehydrogenase flavoprotein from Pantoea cypripedii
KEGG orthology group: K06151, gluconate 2-dehydrogenase alpha chain [EC: 1.1.99.3] (inferred from 76% identity to rah:Rahaq_2101)MetaCyc: 47% identical to D-gluconate dehydrogenase dehydrogenase subunit (Pseudomonas fluorescens)
Gluconate 2-dehydrogenase (acceptor). [EC: 1.1.99.3]
Predicted SEED Role
"Gluconate 2-dehydrogenase (EC 1.1.99.3), membrane-bound, flavoprotein" in subsystem D-gluconate and ketogluconates metabolism (EC 1.1.99.3)
MetaCyc Pathways
- glucose degradation (oxidative) (2/5 steps found)
- L-ascorbate biosynthesis VIII (engineered pathway) (2/7 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.99.3
Use Curated BLAST to search for 1.1.99.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (505 amino acids)
>GFF2665 Gluconate 2-dehydrogenase flavoprotein (Xanthobacter sp. DMC5) MATKLPRKDVVIGCLGWAGAIIANELTDEGLDVIAIERGPWRDTARDFNIETVTDELRYN QRQELMLRTAQNTVTVRNNSSQTALPMRSWGSFHPGNGTGGAGNHWAGITFRFQPGEFRL KSHLTEKYGAGAMPADLTLQDWGTDWDEMEPHYAAFDRIAGISGKAGNIGGKIEEGGNPF EGPRSEEYPNPPLQQPYAPVLFAEAARNLGYKPFPVPSALLSRGYTNPLGVTMGPCTFCG FCTNYGCANYSKASAIIAILPALIRKSNFPVRTNSEVLRVKRDTSGNRATGVVFVDTSGN EWEQPADLVVVAAFTFENVRLMLLSGIGQAYDSPSNTGTTGRNYCYQTANSVQMFFDDKN LNPFIGGGAVGMGIDEFNNDNFDHSGLGFFGGGSVRVTPIGAPPINSRPVPPGTPRWGGE WKRQTVRSYLTTMAIGCEASSYATRGNYLSLDPTYNDRLGRPLLRITFDFPENDLKMASY CTSKVAELARTMGAREIIEHPRRGP