Protein Info for GFF2637 in Sphingobium sp. HT1-2

Annotation: L-Proline/Glycine betaine transporter ProP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 46 to 68 (23 residues), see Phobius details amino acids 88 to 107 (20 residues), see Phobius details amino acids 118 to 143 (26 residues), see Phobius details amino acids 154 to 178 (25 residues), see Phobius details amino acids 190 to 207 (18 residues), see Phobius details amino acids 242 to 266 (25 residues), see Phobius details amino acids 279 to 299 (21 residues), see Phobius details amino acids 308 to 328 (21 residues), see Phobius details amino acids 334 to 356 (23 residues), see Phobius details amino acids 368 to 390 (23 residues), see Phobius details amino acids 401 to 419 (19 residues), see Phobius details PF07690: MFS_1" amino acids 24 to 284 (261 residues), 66.2 bits, see alignment E=2.6e-22 amino acids 280 to 428 (149 residues), 45.6 bits, see alignment E=4.9e-16 PF00083: Sugar_tr" amino acids 24 to 223 (200 residues), 81.8 bits, see alignment E=5.2e-27 amino acids 236 to 425 (190 residues), 31.5 bits, see alignment E=9.6e-12

Best Hits

KEGG orthology group: None (inferred from 66% identity to npp:PP1Y_Mpl5690)

Predicted SEED Role

"L-Proline/Glycine betaine transporter ProP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (432 amino acids)

>GFF2637 L-Proline/Glycine betaine transporter ProP (Sphingobium sp. HT1-2)
MDEETPPMGSPQSLSKRSLAIAGLSTIVEWYDFTLYLYLATLLSRIFYGGGAAGVGHVLA
GFAIAYLMRPLGAIFFGHIGDRHGRRPTMLLSMALMSAAMLATALLPTQAQAGAMAGWLL
LALRCVMAFSVGGEYTGVVAYLLEGAPPGRRGLITSLASAASEVGGLLAVALSALTVALL
DEAALADWGWRMPFLVGAGLAALILLARSRIEDSPDFLAQRARGSIPAQPLRLSLRAYRP
AIGRGFAISALGSITYYVGIVYVPSFLIGTGRMGEADALTLSTLAALVVILVTPLVGALS
DRIGRRPVLVALALAGIALPALLFALMAQGSALGGALLGASLLAALGGAVSAVGAVTTAE
QFPGEGRLSGLAFGATSATALFGGLTPYLSHQLTQASGWASAPGWLIAIVALGVLPVLWR
LPESAPKRQQPC